Aquaporin 4/AQP4 Antibody (B-5): sc-390488

AQP4 Antibody (B-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects AQP4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-AQP4 antibody (B-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AQP4, also known as the mercurial insensitive water channel, plays a crucial role in regulating water homeostasis in the body, particularly in the central nervous system and skeletal muscle. AQP4 is predominantly localized to the sarcolemma of fast-twitch muscle fibers, where AQP4 facilitates rapid water transport, essential for muscle contraction and recovery. AQP4 presence in the brain is vital for maintaining water balance in the extracellular space, which is critical for neuronal function and overall brain health. AQP4 dysregulation has been implicated in various neurological disorders, making AQP4 a significant target for research in understanding and treating conditions such as edema and multiple sclerosis. AQP4′s ability to interact with other proteins, such as dystrophin and glial fibrillary acidic protein, further underscores AQP4′s importance in cellular signaling and structural integrity within tissues.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aquaporin 4/AQP4 Antibody (B-5) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Aquaporin 4/AQP4 Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aquaporin 4/AQP4 Antibody (B-5) Specifications

Alternate Product Name: aquaporin 4

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 244-323

Epitope Target: AQP4

Epitope Species: human

Product Reactivity/Detection: AQP4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Aquaporin 4/AQP4 Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Aquaporin 4/AQP4 antibody is Aquaporin 4/AQP4 Antibody (4/18): sc-32739.