AQP4 Inhibitors
Aquaporin-4 (AQP4) is a member of the aquaporin family of proteins, which are integral membrane proteins responsible for the transport of water across cell membranes. AQP4, in particular, is predominantly expressed in the central nervous system, especially in the astrocytes surrounding the brain's capillaries. The channel formed by AQP4 is selective for water, allowing rapid water movement in response to osmotic gradients. This water channel plays a significant role in maintaining water homeostasis in the brain and spinal cord, contributing to processes like the formation and absorption of cerebrospinal fluid, as well as the maintenance of the blood-brain barrier.
AQP4 inhibitors are a class of chemical compounds designed to specifically inhibit the function of AQP4. These inhibitors work by blocking the water channel, reducing or stopping the flow of water molecules through it. The mechanisms through which these inhibitors achieve their effects can vary. Some might interact directly with the channel's pore, preventing water molecules from passing through. Others might bind to specific sites on the AQP4 protein, causing conformational changes that result in the closure or obstruction of the channel.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-803467 | 944261-79-4 | sc-201068 sc-201068B sc-201068A | 10 mg 25 mg 50 mg | $87.00 $184.00 $342.00 | 1 | |
TGN-020 is a selective AQP4 inhibitor. It blocks the water channel function of AQP4, reducing water flux across cell membranes. | ||||||
Acetazolamide | 59-66-5 | sc-214461 sc-214461A sc-214461B sc-214461C sc-214461D sc-214461E sc-214461F | 10 g 25 g 100 g 250 g 500 g 1 kg 2 kg | $79.00 $174.00 $425.00 $530.00 $866.00 $1450.00 $2200.00 | 1 | |
Acetazolamide, primarily a carbonic anhydrase inhibitor, has been shown to reduce AQP4 expression in certain studies, potentially affecting water balance in the CNS. | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $107.00 $224.00 | 9 | |
Bumetanide is a loop diuretic that can indirectly affect AQP4 function by altering ion gradients and cell osmolarity, which can impact water movement through AQP4. | ||||||
5-Hydroxydecanoate sodium salt | 71186-53-3 | sc-200992 sc-200992A | 100 mg 500 mg | $87.00 $332.00 | 7 | |
5-HD is a mitochondrial K_ATP channel blocker. It has been shown to reduce cerebral edema by potentially down-regulating AQP4 expression. | ||||||
D(−)Mannitol | 69-65-8 | sc-203020A sc-203020 | 50 g 100 g | $10.00 $19.00 | 2 | |
Mannitol, an osmotic diuretic, can affect water movement through AQP4 by altering the osmotic gradient across cell membranes. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
Furosemide, a loop diuretic, might impact AQP4 indirectly by changing ion concentrations and cell osmolarity. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $31.00 $41.00 $159.00 $286.00 | 12 | |
Baicalein, a natural flavonoid, has been reported to reduce AQP4 expression in certain conditions, which can impact water movement in the brain. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone, a corticosteroid, can reduce AQP4 expression in certain inflammatory conditions, potentially impacting water homeostasis in the CNS. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a natural polyphenol, has been reported to reduce AQP4 expression in some experimental settings, potentially affecting water balance in the CNS. | ||||||