Aquaporin 4/AQP4 Antibody (4/18): sc-32739

AQP4 Antibody (4/18) is a mouse monoclonal IgG3 kappa light chain antibody that detects AQP4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and flow cytometry (FCM). Anti-AQP4 antibody (4/18) is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AQP4, also known as aquaporin 4, plays a crucial role in water transport across cell membranes, particularly in the central nervous system and skeletal muscle. AQP4 is predominantly localized to the sarcolemma of fast-twitch muscle fibers, where AQP4 facilitates rapid water movement, essential for muscle function and hydration. This localization helps maintain osmotic balance and supports muscle contraction during intense physical activity. Aquaporins, including AQP4, are integral membrane proteins that form channels allowing selective permeability to water, and aquaporin dysfunction can lead to various pathophysiological conditions, including edema and neurological disorders. The presence of multiple aquaporin isoforms in tissues underscores their importance in diverse physiological processes, such as renal water absorption and the regulation of cerebrospinal fluid dynamics.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Aquaporin 4/AQP4 Antibody (4/18) References:

1. The mammalian aquaporin water channel family: A promising new drug target.  |  Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
2. Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.  |  Preston, GM. and Agre, P. 1991. Proc Natl Acad Sci U S A. 88: 11110-4. PMID: 1722319
3. Structure and chromosomal localization of a human water channel (AQP3) gene.  |  Ishibashi, K., et al. 1995. Genomics. 27: 352-4. PMID: 7558005
4. cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units.  |  Yang, B., et al. 1995. J Biol Chem. 270: 22907-13. PMID: 7559426
5. Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.  |  Deen, PM., et al. 1994. Science. 264: 92-5. PMID: 8140421
6. The human Aquaporin-5 gene. Molecular characterization and chromosomal localization.  |  Lee, MD., et al. 1996. J Biol Chem. 271: 8599-604. PMID: 8621489
7. Cloning and chromosomal localization of mouse aquaporin 4: exclusion of a candidate mutant phenotype, ataxia.  |  Turtzo, LC., et al. 1997. Genomics. 41: 267-70. PMID: 9143504
8. Expression of aquaporin-4 in fast-twitch fibers of mammalian skeletal muscle.  |  Frigeri, A., et al. 1998. J Clin Invest. 102: 695-703. PMID: 9710437
9. Aquaporins.  |  Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Aquaporin 4/AQP4 Antibody (4/18) has 43 citations in a variety of scientific publications.

Primary antibodies like Anti-Aquaporin 4/AQP4 Antibody (4/18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Aquaporin 4/AQP4 Antibody (4/18) Specifications

Alternate Product Name: aquaporin 4

Product Clone Name: 4/18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 301-318

Epitope Target: AQP4

Epitope Species: human

Product Reactivity/Detection: AQP4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 43 citations in various scientific publications

Available Conjugates/Forms for Aquaporin 4/AQP4 Antibody (4/18): AC: Agarose, AF488: Alexa Fluor^® 488, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, PE: Phycoerythrin