17β-HSD2 Antibody (H-12): sc-373990
- 17β-HSD2 Antibody (H-12) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 266-375 mapping near the C-terminus of 17β-HSD2 of human origin
- recommended for detection of 17β-HSD2 of human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for 17β-HSD2 Antibody (H-12) for WB and IHC(P) applications. These reagents are now offered in bundles with 17β-HSD2 Antibody (H-12) (see ordering information below).
17β-HSD2 Antibody (H-12) is a mouse monoclonal IgG2a antibody that detects 17β-HSD2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). 17β-HSD2, or 17β hydroxysteroid dehydrogenase type 2, is a crucial enzyme in the 17β-HSD family that regulates steroid availability within tissues by converting active steroids, such as estradiol and testosterone, into their inactive forms through oxidative activity. This enzymatic function is vital for maintaining hormonal balance, as 17β-HSD2 influences estrogen levels, which has been linked to various health conditions, including breast cancer, colon cancer, and endometriosis. 17β-HSD2 is predominantly localized in the placenta, endometrium, and prostate, but can also be found in the liver, small intestine, and kidney, highlighting its importance in multiple physiological processes. Additionally, 17β-HSD2 functions as a membrane-bound protein, playing a significant role in cellular signaling and hormone regulation. Notably, Tibolone, a medication used to alleviate climacteric symptoms in menopausal women, exerts part of its therapeutic effects by activating 17β-HSD2, further underscoring this enzyme′s relevance in clinical settings.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
17β-HSD2 Antibody (H-12) | sc-373990 | 200 µg/ml | $322.00 | |||
17β-HSD2 Antibody (H-12): m-IgG Fc BP-HRP Bundle | sc-537897 | 200 µg Ab; 10 µg BP | $361.00 | |||
17β-HSD2 Antibody (H-12): m-IgGκ BP-HRP Bundle | sc-535359 | 200 µg Ab; 40 µg BP | $361.00 | |||
17β-HSD2 Antibody (H-12): m-IgG2a BP-HRP Bundle | sc-548141 | 200 µg Ab; 10 µg BP | $361.00 |