ZFP37 Inhibitors
ZFP37 Inhibitors, also known as Zinc Finger Protein 37 Inhibitors, are a specialized class of chemical compounds designed to modulate the activity of the zinc finger transcription factor known as ZFP37. Zinc finger proteins are a diverse family of transcription factors that play crucial roles in gene regulation by binding to specific DNA sequences and either activating or repressing gene expression. ZFP37, in particular, is involved in various biological processes, including embryonic development, cellular differentiation, and immune responses. The development of ZFP37 inhibitors stems from the need to study and manipulate these biological processes at the molecular level.
These inhibitors are meticulously designed to target ZFP37's DNA-binding domain or other critical regions of the protein to interfere with its ability to interact with DNA. By doing so, ZFP37 inhibitors can effectively disrupt the transcriptional regulation of genes under the control of ZFP37, leading to downstream effects on cellular processes. Researchers often employ these inhibitors in laboratory settings to elucidate the precise functions of ZFP37 and understand its role in various physiological and pathological conditions. Additionally, ZFP37 inhibitors can be invaluable tools for investigating the broader zinc finger protein family and their involvement in gene expression control, opening up avenues for fundamental research in molecular biology and genetics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can inhibit DNA methylation, potentially altering the expression of genes including ZFP37. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Intercalates DNA, inhibiting transcription and thus potentially decreasing ZFP37 expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Inhibits ribonucleotide reductase, potentially affecting DNA synthesis and, by extension, gene expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Topoisomerase I inhibitor that can interfere with DNA unwinding and potentially affect transcription of genes including ZFP37. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
RNA polymerase II inhibitor, which can halt transcription processes and potentially reduce ZFP37 expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits RNA polymerase II, potentially leading to reduced transcription of ZFP37. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Known to inhibit cyclin-dependent kinases (CDKs) which can lead to a general decrease in transcription, potentially affecting ZFP37. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Tyrosine kinase inhibitor which may have downstream effects on transcription and potentially affect ZFP37 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Binds to DNA and interferes with transcription factor binding, potentially leading to reduced ZFP37 transcription. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Hsp90 inhibitor which can have downstream effects on several cellular processes, potentially affecting the expression of genes like ZFP37. | ||||||