ZFP37 Antibody (15): sc-293086

ZFP37 Antibody (15) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZFP37 protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-ZFP37 antibody (15) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). As a member of the Krüppel C2H2-type zinc-finger family, ZFP37 is a 630 amino acid nuclear protein characterized by twelve C2H2-type zinc fingers and one KRAB domain, which plays a crucial role in transcriptional regulation. The KRAB domain interacts with KAP1, facilitating recruitment of histone-modifying proteins essential for chromatin remodeling and gene expression regulation. ZFP37 shows high expression in adult testis, with peak levels during spermiogenesis, indicating a significant role in regulating this process. Two isoforms of ZFP37 arise from alternative splicing, further underscoring complexity and potential functional diversity. ZFP37′s ability to modulate transcriptional activity makes this protein an important target for studies related to gene regulation and reproductive biology.

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ZFP37 Antibody (15) References:

1. Complete sequencing and characterization of 21,243 full-length human cDNAs.  |  Ota, T., et al. 2004. Nat Genet. 36: 40-5. PMID: 14702039
2. DNA sequence and analysis of human chromosome 9.  |  Humphray, SJ., et al. 2004. Nature. 429: 369-74. PMID: 15164053
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).  |  Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
4. Mouse ovary developmental RNA and protein markers from gene expression profiling.  |  Herrera, L., et al. 2005. Dev Biol. 279: 271-90. PMID: 15733658
5. Zfp-37, a new murine zinc finger encoding gene, is expressed in a developmentally regulated pattern in the male germ line.  |  Burke, PS. and Wolgemuth, DJ. 1992. Nucleic Acids Res. 20: 2827-34. PMID: 1614869
6. Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.  |  Riddell, J., et al. 2014. Cell. 157: 549-64. PMID: 24766805
7. [Effect of Heixiaoyao Powder on Hippocampal Gene Expression Profile of Alzheimer's Disease Rats].  |  Wu, HY., et al. 2016. Zhongguo Zhong Xi Yi Jie He Za Zhi. 36: 1345-1351. PMID: 30641629
8. Cannabis significantly alters DNA methylation of the human ovarian follicle in a concentration-dependent manner.  |  Fuchs Weizman, N., et al. 2022. Mol Hum Reprod. 28: PMID: 35674367
9. Identification and Validation of Hub Genes and Construction of miRNA-Gene and Transcription Factor-Gene Networks in Adipogenesis of Mesenchymal Stem Cells.  |  Dai, M., et al. 2024. Stem Cells Int. 2024: 5789593. PMID: 39238829
10. A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2.  |  Mack, HG., et al. 1997. Gene. 185: 11-7. PMID: 9034307
11. Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome.  |  Dreyer, SD., et al. 1998. Mamm Genome. 9: 458-62. PMID: 9585434
12. Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae.  |  Grishin, AV., et al. 1998. Genetics. 149: 879-92. PMID: 9611199

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZFP37 Antibody (15) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZFP37 Antibody (15) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZFP37 Antibody (15) Specifications

Alternate Product Name: ZFP37

Product Clone Name: 15

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 5-112

Epitope Target: ZFP37

Epitope Species: mouse

Product Reactivity/Detection: ZFP37

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZFP37 Antibody (15): AC: Agarose, HRP: Horseradish Peroxidase