USP9X Activators
USP9X, a member of the ubiquitin-specific protease (USP) family, serves as a critical regulator of various cellular processes through its deubiquitinating activity. This protein is highly conserved across species and is expressed in diverse tissues and cell types. USP9X plays a multifaceted role in maintaining cellular homeostasis by controlling the stability and activity of numerous substrate proteins involved in key signaling pathways. Functionally, USP9X regulates protein turnover by removing ubiquitin moieties from target proteins, thereby preventing their degradation via the proteasome or lysosome. This process allows USP9X to modulate the abundance and activity of its substrates, impacting various cellular processes such as cell cycle progression, DNA damage repair, signal transduction, and protein trafficking.
Activation of USP9X involves several mechanisms that control its enzymatic activity and substrate specificity. One mode of activation is through post-translational modifications, such as phosphorylation, which can enhance USP9X activity and substrate binding. Additionally, binding of cofactors or adaptor proteins may allosterically regulate USP9X function, either enhancing or inhibiting its deubiquitinating activity. Furthermore, changes in subcellular localization or protein-protein interactions can also influence USP9X activation. For example, translocation of USP9X to specific cellular compartments or association with regulatory proteins may promote its activation in response to cellular cues or signaling events. Overall, the diverse mechanisms of USP9X activation ensure precise control over its deubiquitinating activity, allowing for dynamic regulation of cellular processes in health and disease.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a natural compound that enhances USP9X activity. It has been reported to promote the stabilization of USP9X and increase its deubiquitinase activity. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Pyrvinium Pamoate enhances the catalytic activity of USP9X, leading to increased deubiquitinase activity. The compound modulates ubiquitin-dependent signaling pathways, affecting the stability and function of proteins regulated by USP9X. | ||||||
GW 4064 | 278779-30-9 | sc-218577 | 5 mg | $95.00 | 13 | |
GW4064 is a synthetic agonist for the farnesoid X receptor (FXR), and it indirectly activates USP9X. FXR activation leads to the increased expression of USP9X at the transcriptional level, promoting its abundance in cells. This upregulation enhances USP9X-mediated deubiquitination, influencing the stability and activity of its target proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride is a compound that indirectly activates USP9X. It enhances USP9X stability and promotes its accumulation within cells. This leads to increased deubiquitinase activity, influencing the ubiquitin-dependent signaling pathways and stability of proteins regulated by USP9X. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Thymoquinone is a bioactive compound found in Nigella sativa seeds that enhances USP9X activity. It has been reported to increase the deubiquitinase activity of USP9X, leading to enhanced removal of ubiquitin moieties from target proteins. This modulates the stability and cellular functions of USP9X-regulated proteins. | ||||||
Xanthohumol from hop (Humulus lupulus) | 6754-58-1 | sc-301982 | 5 mg | $361.00 | 1 | |
Xanthohumol is a prenylated flavonoid found in hops that enhances USP9X activity. It has been reported to increase the deubiquitinase activity of USP9X, leading to enhanced removal of ubiquitin moieties from target proteins. This modulates the stability and cellular functions of USP9X-regulated proteins. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that indirectly activates USP9X. It modulates the acetylation status of histones, influencing the expression of USP9X at the transcriptional level. The increased expression of USP9X enhances its deubiquitinase activity, leading to the modulation of ubiquitin-dependent signaling pathways and the stability of target proteins. | ||||||
SMER28 | 307538-42-7 | sc-222320 | 10 mg | $173.00 | ||
SMER28 is a small molecule that indirectly activates USP9X. It induces the expression of USP9X at the transcriptional level, leading to increased deubiquitinase activity. This modulation influences ubiquitin-dependent signaling pathways and the stability of proteins regulated by USP9X. | ||||||
SP2509 | 1423715-09-6 | sc-492604 | 5 mg | $284.00 | ||
SP2509 is a small molecule that directly enhances USP9X activity. It has been reported to promote the stabilization of USP9X and increase its deubiquitinase activity. This leads to the enhanced removal of ubiquitin moieties from target proteins, impacting their stability and cellular functions. | ||||||