Twinfilin-1 Activators
Twinfilin-1 activators are compounds that modulate the activity of Twinfilin-1, a protein that plays a crucial role in the regulation of actin dynamics within the cell. Actin is a fundamental component of the cytoskeleton, serving as the structural framework responsible for various cellular processes, including cell motility, shape changes, and intracellular transport. Twinfilin-1 itself acts as a key regulator of actin filament turnover by binding to actin monomers and preventing their incorporation into growing filaments. This mechanism allows for precise control over actin polymerization and depolymerization, which is crucial for many cellular functions.
Twinfilin-1 activators enhance the activity of Twinfilin-1, thereby promoting actin filament disassembly and turnover. By doing so, these compounds can influence various cellular processes that rely on dynamic actin rearrangements, such as cell migration, cytokinesis, and vesicle trafficking. The molecular mechanisms through which Twinfilin-1 activators operate may vary among different compounds, but their overarching goal is to fine-tune actin dynamics for cellular processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin is a toxin that binds to and stabilizes actin filaments. By promoting actin filament formation and stability, it indirectly activates Twinfilin-1, as Twinfilin-1 plays a role in regulating actin dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts actin filaments by sequestering actin monomers. This disruption activates Twinfilin-1 as it attempts to restore actin filament integrity by binding to actin monomers. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide enhances actin polymerization and, in turn, activates Twinfilin-1 by increasing its interaction with actin filaments. It promotes the formation of stable actin structures that Twinfilin-1 can regulate. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 inhibits the Arp2/3 complex, which is involved in actin filament branching. Inhibition of Arp2/3 indirectly activates Twinfilin-1 by reducing competition for actin monomers, allowing Twinfilin-1 to bind and regulate actin more effectively. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 inhibits the Arp2/3 complex, leading to the activation of Twinfilin-1 by promoting actin filament elongation. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filament assembly by capping filament ends. This disruption can activate Twinfilin-1 by increasing its binding to actin monomers, which are released from the disrupted filaments. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 disrupts actin filament dynamics by inhibiting formin proteins. This inhibition indirectly activates Twinfilin-1 by preventing actin filament nucleation and elongation, making more actin monomers available for Twinfilin-1 to regulate. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), which regulates actin cytoskeleton dynamics. Inhibition of ROCK can indirectly activate Twinfilin-1 by altering actin filament organization and stability. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin specifically inhibits myosin II ATPase activity, leading to changes in actin-myosin interactions and actin filament dynamics. These alterations can activate Twinfilin-1 as it responds to changes in actin dynamics. | ||||||