TFIIH p80 Activators
The category of TFIIH p80 activators encompasses a diverse array of chemical compounds that intricately influence the functional dynamics of the TFIIH p80 subunit, a pivotal component within the transcription factor IIH (TFIIH) complex. TFIIH plays a central role in critical cellular processes, including transcription initiation, DNA repair, and cell cycle regulation. Triptolide, a representative of this class, employs an indirect mechanism to activate TFIIH p80 by impeding transcription. This compound disrupts the function of RNA polymerase II, creating an augmented demand for TFIIH p80 during transcription initiation and elongation. Consequently, this disruption leads to the indirect activation of TFIIH p80, emphasizing the intricate interplay between chemical modulators and the molecular machinery governing transcriptional processes. In a parallel vein, Curcumin contributes to TFIIH p80 activation by indirectly influencing the nucleotide excision repair (NER) pathway. Through its modulatory effects on NER, Curcumin impacts the recruitment and activity of TFIIH p80 during DNA repair processes. This exemplifies the nuanced capacity of chemicals to selectively shape specific pathways associated with TFIIH p80 function, unveiling the multifaceted regulatory landscape that governs cellular responses to DNA damage.
Etoposide and Cisplatin, renowned DNA-damaging agents, exert their influence as TFIIH p80 activators by inducing DNA lesions. These compounds initiate the recruitment and activation of TFIIH p80 during the intricate process of DNA lesion repair. This showcases the profound connection between the cellular DNA damage response and the activation of TFIIH p80, underscoring its critical role in maintaining genomic integrity. Further enriching the spectrum of TFIIH p80 activators, Flavopiridol, a cyclin-dependent kinase inhibitor, operates indirectly by influencing cell cycle progression. Its modulation of the cell cycle-dependent recruitment of TFIIH p80 during transcription and repair processes highlights the dynamic interplay between cell cycle regulation and TFIIH p80 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, indirectly activates TFIIH p80 by inducing DNA damage. The DNA lesions generated by etoposide trigger the recruitment and activation of TFIIH p80 during the repair of DNA strand breaks, leading to increased TFIIH p80 activity. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin, a platinum-based chemotherapy drug, indirectly activates TFIIH p80 by causing DNA damage. The formation of DNA adducts by cisplatin triggers the recruitment and activation of TFIIH p80 during the repair of DNA lesions, leading to increased TFIIH p80 activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D, an RNA synthesis inhibitor, indirectly activates TFIIH p80 by disrupting transcription. It inhibits RNA polymerase II function, leading to increased demand for TFIIH p80 during transcription initiation and elongation, resulting in indirect TFIIH p80 activation. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin, a DNA polymerase inhibitor, indirectly activates TFIIH p80 by disrupting DNA synthesis. It induces replication stress, triggering the recruitment and activation of TFIIH p80 during DNA repair processes, leading to increased TFIIH p80 activity indirectly. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C, an antitumor antibiotic, indirectly activates TFIIH p80 by inducing DNA crosslinks. The formation of DNA adducts by mitomycin C triggers the recruitment and activation of TFIIH p80 during the repair of DNA lesions, leading to increased TFIIH p80 activity indirectly. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil, an antimetabolite, indirectly activates TFIIH p80 by influencing nucleotide metabolism. It modulates the availability of nucleotides during DNA synthesis, leading to increased demand for TFIIH p80 during replication processes, resulting in indirect TFIIH p80 activation. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, a PARP inhibitor, indirectly activates TFIIH p80 by affecting DNA repair processes. It modulates the recruitment and activity of TFIIH p80 during the repair of DNA lesions, leading to increased TFIIH p80 activation indirectly in the context of poly(ADP-ribose) polymerase inhibition. | ||||||