TFIIH p80 Inhibitors
TFIIH p80 inhibitors are a class of chemical compounds that specifically target and inhibit the p80 subunit of the transcription factor IIH (TFIIH) complex. TFIIH is a multifunctional protein complex involved in transcription initiation and DNA repair. The p80 subunit, also known as GTF2H1, plays a critical role in stabilizing the complex and facilitating its involvement in both nucleotide excision repair (NER) and the transcription of genes by RNA polymerase II. In transcription, TFIIH is responsible for unwinding DNA to allow RNA polymerase II access to the template strand. By targeting the p80 subunit, TFIIH p80 inhibitors disrupt the function of this complex, impairing its role in the transcription initiation process and the repair of damaged DNA.
Chemically, TFIIH p80 inhibitors are designed to interfere with the protein-protein interactions necessary for p80 to stabilize and organize the TFIIH complex. These inhibitors may bind directly to the p80 subunit, preventing it from properly interacting with other components of the TFIIH complex, such as the helicase XPB or XPD. Alternatively, some inhibitors may cause conformational changes in p80, weakening its ability to participate in the formation of the active TFIIH complex. High-throughput screening and structure-activity relationship (SAR) studies are used to optimize the specificity of these inhibitors, ensuring they effectively target the p80 subunit without affecting other transcription factors or repair complexes. By inhibiting TFIIH p80, researchers can investigate the specific roles of this subunit in transcription and DNA repair, exploring the intricate regulatory mechanisms that govern gene expression and the maintenance of genomic integrity. These inhibitors provide valuable tools for studying the coordination of transcription and DNA repair processes in cells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is a diterpene triepoxide that indirectly influences TFIIH p80 by inhibiting transcription factor IIH (TFIIH) activity. This indirect modulation can impact TFIIH p80's role in transcription initiation and nucleotide excision repair, potentially leading to disruptions in DNA damage response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a natural polyphenol, indirectly modulates TFIIH p80 by affecting various cellular pathways, including inflammatory and oxidative stress pathways. This indirect modulation can influence TFIIH p80's function in transcription and DNA repair processes, potentially contributing to altered genomic stability. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
Flavopiridol is a synthetic flavonoid that indirectly modulates TFIIH p80 by inhibiting cyclin-dependent kinases (CDKs). This indirect inhibition affects TFIIH p80's involvement in transcription regulation, potentially leading to alterations in DNA repair processes and genomic stability. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB is a synthetic compound that directly inhibits the kinase activity of CDK7, a component of the TFIIH complex. This direct inhibition impacts TFIIH p80's role in transcription initiation, potentially leading to disruptions in DNA damage response and repair processes. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $149.00 $826.00 | 14 | |
Triacsin C is a synthetic fatty acyl-coA synthetase inhibitor that indirectly modulates TFIIH p80 by affecting lipid metabolism. This indirect modulation can influence TFIIH p80's function in transcription and DNA repair processes, potentially contributing to altered genomic stability. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
DRB HCl is a salt form of DRB, a synthetic compound that directly inhibits the kinase activity of CDK7, impacting TFIIH p80's role in transcription initiation. This direct inhibition can lead to disturbances in DNA damage response and repair processes. | ||||||
PP1 Analog II, 1NM-PP1 | 221244-14-0 | sc-203214 sc-203214A | 1 mg 5 mg | $106.00 $520.00 | 10 | |
NM-PP1 is a synthetic inhibitor that directly targets CDK7, a component of the TFIIH complex. This direct inhibition affects TFIIH p80's role in transcription initiation, potentially leading to disruptions in DNA damage response and repair processes. | ||||||
TBB | 17374-26-4 | sc-202830 sc-202830A sc-202830C sc-202830B sc-202830D | 10 mg 25 mg 50 mg 100 mg 250 mg | $240.00 $363.00 $445.00 $760.00 $1781.00 | 17 | |
TBB is a synthetic compound that indirectly modulates TFIIH p80 by inhibiting CDK7. This indirect inhibition affects TFIIH p80's role in transcription initiation, potentially leading to disruptions in DNA damage response and repair processes. | ||||||