RGS1 Activators
The chemical class of RGS1 activators is not characterized by direct interaction with the RGS1 protein; instead, these compounds modulate cellular signaling pathways, particularly those involving cAMP, indirectly influencing the activity of RGS1. RGS1 (Regulator of G protein Signaling 1) plays a role in terminating the signaling activity of G proteins, and its activity is intricately linked to the overall dynamics of G protein-coupled receptor (GPCR) signaling pathways.
This class of compounds, including forskolin, epinephrine, and various phosphodiesterase inhibitors, primarily functions by manipulating the levels of cAMP within the cell. An increase in cAMP typically results from the activation of adenylate cyclase or inhibition of phosphodiesterases, enzymes responsible for cAMP degradation. Higher cAMP levels can promote the activation of protein kinase A (PKA), which subsequently influences various cellular processes, including those modulating GPCR signaling. Since RGS1 is a critical regulator in the GPCR pathway, alterations in cAMP levels and the subsequent cascade of events can indirectly influence the activity of RGS1. Additionally, compounds like dopamine and salbutamol, which act as agonists for specific GPCRs, contribute to the modulation of cAMP levels and thereby create a cellular context that can indirectly impact RGS1 activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. Higher cAMP can indirectly enhance RGS1 activity by promoting G protein-mediated signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
A non-selective inhibitor of phosphodiesterases, leading to increased cAMP levels which can enhance RGS1 activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
A hormone and neurotransmitter that can increase cAMP levels indirectly influencing RGS1 activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
A selective inhibitor of phosphodiesterase 4, increases cAMP levels thereby can indirectly activate RGS1. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
A phosphodiesterase 3 inhibitor, increases cAMP levels and can indirectly influence RGS1 activity. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
A synthetic catecholamine and non-selective β-adrenergic agonist, increases cAMP and can indirectly activate RGS1. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $31.00 $145.00 | 16 | |
Activates adenylate cyclase through its receptor, increasing cAMP levels, and can indirectly enhance RGS1 activity. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Through certain receptors, can increase cAMP levels, indirectly influencing RGS1 activity. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
A β2-adrenergic agonist, can increase cAMP levels, indirectly enhancing RGS1 activity. | ||||||