Pin4 Activators
PIN4 activators refer to a chemical class encompassing compounds that can indirectly modulate the activity of the PIN4 protein through their interactions with cellular pathways and processes. PIN4, a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, plays a role in catalyzing the cis-trans isomerization of proline peptide bonds in proteins. One subset of PIN4 activators includes immunosuppressive agents like Cyclosporin A and FK506, which interact with cyclophilins and FKBP proteins, respectively. These interactions can indirectly affect PIN4 by modulating peptidyl-prolyl cis-trans isomerase (PPIase) activity within the cell. Additionally, cellular stress inducers like heat shock, oxidative stress agents such as hydrogen peroxide, and proteasome inhibitors like MG-132 can indirectly impact PIN4 by affecting cellular stress responses, redox balance, and protein turnover. Histone deacetylase (HDAC) inhibitors such as Trichostatin A and ubiquitin E1 inhibitors like PYR-41 can influence gene expression patterns and ubiquitin-mediated processes that intersect with PIN4-regulated pathways. Finally, protein kinase inhibitors like Staurosporine may influence cellular signaling pathways that involve PIN4-mediated functions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Binds to cyclophilins, potentially impacting PIN4-mediated protein folding. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Interacts with FKBP proteins, indirectly influencing PIN4 through PPIase modulation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Induces oxidative stress, indirectly impacting PIN4 activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Inhibition of the proteasome affects protein turnover and stability, potentially influencing PIN4. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Inhibits histone deacetylases, altering gene expression, potentially impacting PIN4. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Inhibits ubiquitin-activating enzyme E1, disrupting ubiquitin-mediated processes that may involve PIN4. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Impacts cellular signaling pathways, potentially impacting PIN4-mediated processes. | ||||||