Pin4 Inhibitors
Items 1 to 10 of 14 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Juglone | 481-39-0 | sc-202675 sc-202675A | 1 g 5 g | $66.00 $222.00 | 6 | |
Juglone, CAS 481-39-0, is a naphthoquinone compound that acts as an inhibitor of the peptidyl-prolyl cis-trans isomerase Pin4 by interfering with its isomerase activity, which affects protein folding. | ||||||
PPIase-Parvulin Inhibitor | 64005-90-9 | sc-222187 | 10 mg | $200.00 | ||
PPIase-Parvulin Inhibitor, CAS 64005-90-9, is a chemical that inhibits Pin4 by targeting its peptidyl-prolyl cis-trans isomerase activity, which is pivotal in protein folding processes. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK-506 binds to the immunophilin FKBP12, creating a complex that inhibits calcineurin. Inhibition of calcineurin affects Pin4 by altering its ability to engage in phosphorylation-dependent interactions. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A forms a complex with cyclophilins, inhibiting calcineurin. The subsequent downregulation of dephosphorylation processes can indirectly inhibit Pin4 functions related to cell cycle regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12, but instead of inhibiting calcineurin, it inhibits mTOR. This can lead to decreased protein synthesis and indirectly affect Pin4 activity due to reduced cell growth signals. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin binds to heat shock protein 90 (Hsp90) and interferes with its chaperone function. This can lead to destabilization of client proteins, potentially affecting Pin4's folding and stability. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora kinase inhibitor which interferes with mitotic spindle assembly. This can hinder cell division processes where Pin4 is implicated, leading to its functional inhibition. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic acid inhibits farnesyl pyrophosphate synthase, disrupting prenylation. This could affect the localization and function of Pin4 by altering its post-translational modifications. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that prevents activation of ERK1/2, components of the MAPK pathway. By inhibiting this pathway, the phosphorylation status of Pin4 targets might be altered, indirectly affecting Pin4's role. | ||||||
WZ4003 | 1214265-58-3 | sc-473979 | 5 mg | $300.00 | ||
WZ4003 is a selective NUAK1 inhibitor which could inhibit cellular processes involving Pin4 by disrupting its interaction with substrates phosphorylated by NUAK1. | ||||||