Molecular structure of PPIase-Parvulin Inhibitor, CAS Number: 64005-90-9
PPIase-Parvulin Inhibitor (CAS 64005-90-9)
Alternate Names:
PiB; HIC 016C; Diethyl-1,3,6,8-tetrahydro-1,3,6,8-tetraoxobenzo[lmn][3,8]phenanthroline-2,7-diacetate
Application:
PPIase-Parvulin Inhibitor is a Pin1/Pin4 PPIase activity inhibitor
CAS Number:
64005-90-9
Purity:
≥95%
Molecular Weight:
438.4
Molecular Formula:
C22H18N2O8
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
PPIase-Parvulin Inhibitor is a cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties. PPIase-Parvulin Inhibitor causes cell cycle arrest and acts as a potent, competitive, selective, reversible, active site binding inhibitor of Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity.
PPIase-Parvulin Inhibitor (CAS 64005-90-9) References
- Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. | Uchida, T., et al. 2003. Chem Biol. 10: 15-24. PMID: 12573694
- Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin. | Grison, A., et al. 2011. Proc Natl Acad Sci U S A. 108: 17979-84. PMID: 22011578
- Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells. | Farra, R., et al. 2015. Biochimie. 112: 85-95. PMID: 25742740
- Targeting peptidyl-prolyl isomerase pin1 to inhibit tumor cell aggressiveness. | Beretta, GL., et al. 2016. Tumori. 102: 144-9. PMID: 26917410
- A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. | Campaner, E., et al. 2017. Nat Commun. 8: 15772. PMID: 28598431
- GC-MS Analysis, Antibacterial, and Anticancer Activities of Hibiscus sabdariffa L. Methanolic Extract: In Vitro and In Silico Studies. | Sehim, AE., et al. 2023. Microorganisms. 11: PMID: 37375103
Inhibitor of:
Pin1, and Pin4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PPIase-Parvulin Inhibitor, 10 mg | sc-222187 | 10 mg | $200.00 |