LOC390937_EG232974 Activators
LOC390937_EG232974 Activators function primarily by enhancing the intracellular levels of cyclic adenosine monophosphate (cAMP), a pivotal second messenger in many cellular processes. Forskolin, PGE2, Isoprenaline, Epinephrine, Dopamine, SKF38393, and BRL 37344 increase intracellular cAMP levels by activating adenylate cyclase or specific receptors linked to adenylate cyclase. This leads to the activation of protein kinase A (PKA), which can then phosphorylate and activate LOC390937_EG232974.
On the other hand, IBMX, Rolipram, and ZM241385 raise intracellular cAMP levels by inhibiting phosphodiesterase or the A2A adenosine receptor, which normally decreases cAMP levels. This facilitates the functional activation of LOC390937_EG232974. These compounds act on specific pathways or biological processes directly involved in LOC390937_EG232974 function, leading to its enhanced activity. 8-Bromo-cAMP directly activates PKA, bypassing the need for increased cAMP levels. H-89, by contrast, inhibits PKA, reducing the negative feedback inhibition on LOC390937_EG232974, and thereby enhancing its activity.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP directly activates PKA, bypassing the need for increased cAMP levels, thus leading to phosphorylation and activation of LOC390937_EG232974. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a PKA inhibitor. By inhibiting PKA, it reduces the negative feedback inhibition on LOC390937_EG232974, thereby enhancing its activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX enhances the functional activity of LOC390937_EG232974 by inhibiting phosphodiesterase, which increases cAMP levels, stimulating PKA, leading to phosphorylation and activation of LOC390937_EG232974. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase, leading to increased cAMP levels, PKA stimulation, and subsequent phosphorylation and activation of LOC390937_EG232974. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 enhances the functional activity of LOC390937_EG232974 by activating adenylate cyclase, which increases cAMP levels. The elevated cAMP levels stimulate PKA, leading to phosphorylation and activation of LOC390937_EG232974. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoprenaline activates beta-adrenergic receptors, increasing cAMP levels. The enhanced cAMP levels stimulate PKA, leading to phosphorylation and activation of LOC390937_EG232974. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine increases cAMP levels through its action as a beta-adrenergic receptor agonist. The enhanced cAMP levels stimulate PKA, leading to phosphorylation and activation of LOC390937_EG232974. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine, a D1-like receptor agonist, increases cAMP levels. The elevated cAMP levels stimulate PKA, leading to phosphorylation and activation of LOC390937_EG232974. | ||||||
SKF 38393 hydrochloride | 62717-42-4 | sc-203264 | 25 mg | $50.00 | ||
SKF38393 is a D1-like receptor agonist that increases cAMP levels. The elevated cAMP levels stimulate PKA, which then phosphorylates and activates LOC390937_EG232974. | ||||||
BRL-37344 | 127299-93-8 | sc-200154 | 5 mg | $130.00 | 7 | |
BRL 37344, a beta3-adrenergic receptor agonist, increases cAMP levels. The elevated cAMP levels stimulate PKA, which then phosphorylates and activates LOC390937_EG232974. | ||||||