Molecular structure of BRL-37344, CAS Number: 127299-93-8
BRL-37344 (CAS 127299-93-8)
See product citations (7)
Alternate Names:
BRL-37344 Sodium Salt
Application:
BRL-37344 is a potent and selective β3-AR agonist
CAS Number:
127299-93-8
Purity:
98%
Molecular Weight:
385.82
Molecular Formula:
C19H21ClNO4•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BRL-37344 is a beta3-AR (beta 3-adrenoceptor) selective agonist with lipolytic activity. The beta 3 receptor has been reported to have a high affinity towards BRL-37344. Studies show that BRL-373344 promotes thermogenesis and its RR enantiomer acts as a stronger agonist in brown adipocytes in comparison to white adipocytes. Analysis of BRL-37344, isoproterenol, and norepinephrine showed BRL-37344 to be the most potent agonist. BRL-37344 is an activator of beta2-AR and beta1-AR.
BRL-37344 (CAS 127299-93-8) References
- BRL 37344 inhibited adrenergic transmission in the rat portal vein via atypical beta-adrenoceptors. | Yousif, MH. and Oriowo, MA. 2002. Pharmacol Res. 45: 313-7. PMID: 12030795
- Comparison of the lipolytic effects of norepinephrine and BRL 37344 in rat brown and white adipocytes. | Simard, PM., et al. 1994. Obes Res. 2: 424-31. PMID: 16353594
- Comparison of effects of formoterol and BRL 37344 on isolated term-pregnant rat myometrial strips in vitro. | Yurtcu, N., et al. 2006. Eur J Pharmacol. 530: 263-9. PMID: 16388799
- Molecular cloning and expression of the rat beta 3-adrenergic receptor. | Granneman, JG., et al. 1991. Mol Pharmacol. 40: 895-9. PMID: 1684635
- Relaxant effects of beta-adrenoceptor agonist formoterol and BRL 37344 on bovine iris sphincter and ciliary muscle. | Topalkara, A., et al. 2006. Eur J Pharmacol. 548: 144-9. PMID: 16973159
- An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity. | Muzzin, P., et al. 1991. J Biol Chem. 266: 24053-8. PMID: 1721063
- A preadipocyte clonal line from mouse brown adipose tissue. Short- and long-term responses to insulin and beta-adrenergics. | Forest, C., et al. 1987. Exp Cell Res. 168: 218-32. PMID: 2877896
- ATP-sensitive and maxi potassium channels regulate BRL 37344-induced tocolysis in buffaloes-an in vitro study. | Sharma, V., et al. 2018. Theriogenology. 107: 194-202. PMID: 29172176
- Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice1. | Carvalho, MF., et al. 2019. Acta Cir Bras. 34: e201900205. PMID: 30843938
- Coexisting beta-adrenoceptor subtypes: significance for thermogenic process in brown fat cells. | Zhao, J., et al. 1994. Am J Physiol. 267: C969-79. PMID: 7943293
- Positive chronotropic and inotropic responses to BRL 37344, a beta 3-adrenoceptor agonist in isolated, blood-perfused dog atria. | Takayama, S., et al. 1993. Eur J Pharmacol. 231: 315-21. PMID: 8095462
- Correlation of beta 3-adrenoceptor-induced activation of cyclic AMP-dependent protein kinase with activation of lipolysis in rat white adipocytes. | Murphy, GJ., et al. 1993. Biochem Pharmacol. 46: 575-81. PMID: 8103324
- The selectivity in vitro of the stereoisomers of the beta-3 adrenoceptor agonist BRL 37344. | Oriowo, MA., et al. 1996. J Pharmacol Exp Ther. 277: 22-7. PMID: 8613923
Inhibitor of:
β3Gn-T2.Activator of:
beta1-AR, beta2-AR, beta3-AR, dHAND, GS188, LOC390937_EG232974, and MC5-R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BRL-37344, 5 mg | sc-200154 | 5 mg | $130.00 |