Kar9 Activators
Kar9 is a key protein in Saccharomyces cerevisiae, commonly known as baker's or brewer's yeast, and plays a crucial role in cell division. It is integral to the process of mitotic spindle orientation and positioning, ensuring accurate chromosome segregation and proper cell division. Kar9's function is particularly important for the asymmetric cell division seen in yeast, where one large mother cell gives rise to a smaller daughter cell.During cell division, the mitotic spindle, a structure composed of microtubules, must align along the mother-daughter axis to ensure that each cell inherits the correct number of chromosomes. Kar9 is involved in orienting the spindle by localizing to one end of the spindle pole body (the yeast equivalent of the centrosome in animal cells) and interacting with the cytoskeleton, specifically the microtubules.
Kar9 achieves this by binding to microtubule plus-end-binding proteins (such as Bim1) and motor proteins (like Myo2), effectively guiding the microtubules towards the bud site – the location where the daughter cell will form. This interaction is vital for the asymmetric distribution of astral microtubules, which are essential for proper spindle positioning and the accurate segregation of chromosomes.Mutations or dysfunctions in Kar9 can lead to errors in spindle positioning, resulting in incorrect chromosome segregation. This can have significant consequences, including aneuploidy, where cells have an abnormal number of chromosomes, leading to cell death or malfunction.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea induces replication stress, potentially enhancing Kar9 expression as part of the cell cycle checkpoint response. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, possibly upregulating Kar9 in response to spindle assembly checkpoint activation. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and might influence Kar9 expression related to spindle dynamics. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine, by disrupting microtubules, could enhance Kar9 expression as part of a cellular response to impaired spindle function. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin induces DNA damage, potentially triggering Kar9 expression in response to genomic instability. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide causes DNA breaks and could upregulate Kar9 as part of the cellular DNA damage response. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin causes DNA crosslinks, potentially enhancing Kar9 expression in response to impaired DNA replication. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C induces DNA crosslinking, potentially enhancing Kar9 expression in response to replication stress. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, by causing DNA damage, may trigger Kar9 expression in the DNA damage checkpoint pathway. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, possibly inducing Kar9 expression due to replication stress and DNA damage. | ||||||