GLYATL1 Activators
Chemical activators of GLYATL1 play a crucial role in the enzyme's ability to catalyze the conjugation of glycine with acyl CoA substrates. A key substrate is Acetyl-CoA, a molecule central to numerous metabolic pathways. Acetyl-CoA's availability is influenced by various compounds, each contributing to the pool of substrates necessary for GLYATL1's optimal functioning. Citric acid, an intermediate in the citric acid cycle, is metabolized to yield Acetyl-CoA, thus enhancing GLYATL1's activity by supplying its substrate. Similarly, alpha-ketoglutarate and succinic acid, both participants in the citric acid cycle, eventually lead to the production of Acetyl-CoA. Malic acid and fumaric acid, also components of the citric acid cycle, contribute to the generation of Acetyl-CoA, underlining the cycle's importance in maintaining the activation state of GLYATL1.
Other compounds indirectly influence GLYATL1 activity by modulating the levels of Acetyl-CoA. Pyruvic acid is converted into Acetyl-CoA, thus serving as a precursor that supports the enzyme's activation. L-Carnitine has a role in transporting fatty acids into the mitochondria, where beta-oxidation occurs, yielding additional Acetyl-CoA for GLYATL1 activation. Coenzyme A (CoA) is necessary for the formation of Acetyl-CoA, and its availability is a determinant for GLYATL1 function. Nicotinamide adenine dinucleotide (NAD+) and adenosine triphosphate (ATP), although not direct substrates for GLYATL1, contribute to the energy balance and the biochemical pathways that produce Acetyl-CoA, thereby ensuring that GLYATL1 has the necessary components for its activation and subsequent metabolic actions.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Acetyl coenzyme A trisodium salt | 102029-73-2 | sc-210745 sc-210745A sc-210745B | 1 mg 5 mg 1 g | $47.00 $92.00 $5826.00 | 3 | |
Acetyl-CoA serves as a substrate for GLYATL1 in the acetylation reaction, leading to the activation of GLYATL1’s enzymatic activity in the conjugation of glycine with acyl CoA substrates. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine is a substrate for GLYATL1 and is necessary for the enzyme's activity. By binding to GLYATL1, glycine enables the enzyme to catalyze the conjugation of acyl substrates, thereby activating GLYATL1's function in metabolic pathways. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ can enhance GLYATL1 activity indirectly by being a cofactor in reactions producing Acetyl-CoA, which is a substrate for GLYATL1, thus potentially increasing GLYATL1 substrate availability and its activation. | ||||||
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $83.00 $135.00 $418.00 $801.00 | 1 | |
CoA is a cofactor that, in its acetylated form as Acetyl-CoA, serves as a substrate for GLYATL1. The availability of CoA can indirectly increase the formation of Acetyl-CoA, thereby enhancing GLYATL1 activation. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP provides the energy necessary for many biochemical reactions and can indirectly support the synthesis of Acetyl-CoA, subsequently promoting the activation of GLYATL1 by increasing substrate availability. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $50.00 $110.00 $145.00 $248.00 $598.00 | 1 | |
Citric acid is an intermediate in the citric acid cycle that leads to the production of Acetyl-CoA, indirectly supporting the activation of GLYATL1 by providing more of its substrate. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine facilitates the transport of fatty acids into mitochondria for beta-oxidation, which produces Acetyl-CoA, indirectly enhancing the activation of GLYATL1 by increasing its substrate concentration. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-ketoglutarate is part of the citric acid cycle and is involved in the production of Acetyl-CoA, which is a substrate for GLYATL1, thus indirectly supporting GLYATL1 activation. | ||||||
Malic acid | 6915-15-7 | sc-257687 | 100 g | $130.00 | 2 | |
Malic acid is a part of the citric acid cycle that contributes to the production of Acetyl-CoA. The increased production of Acetyl-CoA can lead to an indirect activation of GLYATL1. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $41.00 $96.00 | ||
Pyruvic acid is converted into Acetyl-CoA, which is necessary for the activation of GLYATL1, thus pyruvic acid indirectly supports the activation of GLYATL1 by contributing to its substrate pool. | ||||||