GLYATL1 Antibody (B-12): sc-515030

GLYATL1 Antibody (B-12) is a mouse monoclonal IgM antibody that detects GLYATL1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GLYATL1 antibody (B-12) is available as the non-conjugated form. GLYATL1, also known as glycine N-acyltransferase-like protein 1 or GNAT, is a 302 amino acid mitochondrial acyltransferase that plays a crucial role in amino acid metabolism by transferring acyl groups to glycine′s N-terminus, facilitating various N-acylglycines formation. This enzymatic activity contributes to metabolic pathway regulation and detoxification of acyl-CoA derivatives, which can become toxic at high concentrations. GLYATL1 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 11q12.1, a region associated with several genetic disorders, including Jervell and Lange-Nielsen syndrome and Niemann-Pick disease. GLYATL1′s ability to conjugate multiple substrates underscores its importance in cellular metabolism and highlights its potential as a target for therapeutic interventions in metabolic disorders.

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GLYATL1 Antibody (B-12) References:

1. The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease.  |  Schuchman, EH. 2007. J Inherit Metab Dis. 30: 654-63. PMID: 17632693
2. Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome).  |  Coldren, CD., et al. 2009. Neurogenetics. 10: 89-95. PMID: 18855024
3. An intronic mutation leading to incomplete skipping of exon-2 in KCNQ1 rescues hearing in Jervell and Lange-Nielsen syndrome.  |  Bhuiyan, ZA., et al. 2008. Prog Biophys Mol Biol. 98: 319-27. PMID: 19027783
4. An immunodetection method for the quantitation of human acyl CoA:glycine N-acyltransferase in biological samples.  |  Mawal, YR. and Qureshi, IA. 1994. Biochem Mol Biol Int. 34: 595-601. PMID: 7833837
5. Fatty acid amide biosynthesis: a possible new role for peptidylglycine alpha-amidating enzyme and acyl-coenzyme A: glycine N-acyltransferase.  |  Merkler, DJ., et al. 1996. Arch Biochem Biophys. 330: 430-4. PMID: 8660675
6. Developmental profile of mitochondrial glycine N-acyltransferase in human liver.  |  Mawal, Y., et al. 1997. J Pediatr. 130: 1003-7. PMID: 9202629
7. Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man.  |  Webster, LT., et al. 1976. J Biol Chem. 251: 3352-8. PMID: 931988

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GLYATL1 Antibody (B-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GLYATL1 Antibody (B-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GLYATL1 Antibody (B-12) Specifications

Alternate Product Name: GLYATL1

Product Clone Name: B-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 265-279

Epitope Target: GLYATL1

Epitope Species: human

Product Reactivity/Detection: GLYATL1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GLYATL1 Antibody (B-12): P: Blocking Peptide