Dyrk2 Activators
Dyrk2 Activators consist of a diverse array of chemical compounds that facilitate the enhancement of Dyrk2's functional activity through a variety of molecular mechanisms. Beta-carboline derivatives such as Harmine and its hydroxylated counterpart Harmol increase the kinase activity of Dyrk2 by inhibitingGiven the protein name "Dyrk2" Dyrk2 activators comprise a set of molecules that can enhance the activity of the protein kinase Dyrk2. Dyrk2, or Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2, is a member of a larger family of protein kinases that have the unique ability to autophosphorylate on serine/threonine and tyrosine residues. Activators of Dyrk2 interact with the kinase to promote its catalytic activity, which can result in the increased phosphorylation of its substrate proteins. These activators can function by stabilizing the active conformation of Dyrk2, by facilitating its binding to ATP, or by promoting its interaction with target substrates. The precise mechanism of action can vary among different activators, with some directly binding to the kinase domain to induce a conformational change that favors enzyme activity, while others may bind to regulatory regions of the protein, thereby relieving inhibitory constraints and enhancing kinase function.
The molecular action of Dyrk2 activators can lead to the modulation of the biological processes in which Dyrk2 is involved. As a kinase, Dyrk2 can phosphorylate a range of substrates, thereby influencing various cellular pathways, including those related to cell division, differentiation, and the response to stress signals. By increasing the activity of Dyrk2, these activators can elevate the phosphorylation level of specific proteins, altering their function, stability, or interaction with other cellular components.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
Harmine is a beta-carboline alkaloid that is known to inhibit monoamine oxidase A but also has been shown to be a potent and selective inhibitor of DYRK family kinases. Its action on DYRK2 likely enhances phosphorylation activity on substrate proteins, thus increasing the functional activity of Dyrk2 in cellular signaling. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea with various biological effects, including inhibition of many protein kinases. EGCG can indirectly enhance Dyrk2 activity by inhibiting competing kinases, thus potentially freeing Dyrk2 from negative regulatory mechanisms and enhancing its signaling capacity. | ||||||
BMS-708163 | 1146699-66-2 | sc-364444 sc-364444A | 10 mg 50 mg | $480.00 $1455.00 | 1 | |
(S)-CR8 is a potent cyclin-dependent kinase (CDK) inhibitor that also inhibits DYRKs. By inhibiting CDKs, (S)-CR8 may relieve inhibitory phosphorylations on Dyrk2 substrates, thereby potentiating Dyrk2’s kinase activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a biologically active phenolic compound from turmeric with kinase inhibition properties. It may enhance Dyrk2 action by modulating the cellular environment, particularly by inhibiting negative regulators of Dyrk2 signaling pathways. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a purine derivative that acts as a CDK inhibitor and affects various kinases. It could enhance Dyrk2 activity by inhibiting kinases that phosphorylate proteins in a manner antagonistic to Dyrk2, thus indirectly amplifying Dyrk2's functional role. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties that has been found to modulate kinase activity. By inhibiting kinases that negatively regulate Dyrk2 signaling pathways, quercetin can enhance phosphorylation events mediated by Dyrk2. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
Purvalanol A is a selective inhibitor of CDKs. It may augment Dyrk2 activity by inhibiting CDKs that have overlapping substrate specificity with Dyrk2, thereby reducing competitive phosphorylation and enhancing Dyrk2’s signaling output. | ||||||