Dyrk2 Antibody (6E2): sc-293487

Dyrk2 Antibody (6E2) is a mouse monoclonal IgG3 kappa light chain antibody that detects the Dyrk2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Dyrk2 antibody (6E2) is available as the non-conjugated format. Dyrk2, a member of the dual specificity tyrosine phosphorylation regulated kinase family, plays a crucial role in various cellular processes, including neurogenesis, by regulating the phosphorylation of both tyrosine and serine/threonine residues. This dual specificity enables Dyrk2 to modulate signaling pathways essential for cell differentiation and development. Dyrk2 shares homology with the Drosophila minibrain gene, which is critical for proper neurodevelopment. Multiple isoforms of Dyrk2 exist, including a 528-amino acid protein and a longer variant with an additional 73 amino acids at the amino terminus, suggesting a complex regulatory mechanism that influences activity and cellular interactions. The Dyrk family, which includes Dyrk1A, Dyrk1B, Dyrk1C, Dyrk3, and Dyrk4, contributes to various cellular functions, with Dyrk1A showing association with Down syndrome through overexpression in affected individuals. Dyrk2 and related genes are located on human chromosomes 12 and 1q32, highlighting evolutionary significance and potential therapeutic applications.

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Dyrk2 Antibody (6E2) References:

1. Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome.  |  Guimera, J., et al. 1999. Genomics. 57: 407-18. PMID: 10329007
2. Engagement of DYRK2 in proper control for cell division.  |  Nihira, NT. and Yoshida, K. 2015. Cell Cycle. 14: 802-7. PMID: 25603354
3. Multiple functions of DYRK2 in cancer and tissue development.  |  Yoshida, S. and Yoshida, K. 2019. FEBS Lett. 593: 2953-2965. PMID: 31505048
4. DYRK2 controls a key regulatory network in chronic myeloid leukemia stem cells.  |  Park, CS. and Lacorazza, HD. 2020. Exp Mol Med. 52: 1663-1672. PMID: 33067577
5. Emerging roles of DYRK2 in cancer.  |  Tandon, V., et al. 2021. J Biol Chem. 296: 100233. PMID: 33376136
6. Dyrk2 gene transfer suppresses hepatocarcinogenesis by promoting the degradation of Myc and Hras.  |  Kamioka, H., et al. 2023. JHEP Rep. 5: 100759. PMID: 37333975
7. DYRK2 promotes chemosensitivity via p53-mediated apoptosis after DNA damage in colorectal cancer.  |  Takano, Y., et al. 2023. Cancer Sci. 114: 4558-4570. PMID: 37776195
8. Functional Roles of DYRK2 as a Tumor Regulator.  |  Mochimaru, Y. and Yoshida, K. 2023. Curr Issues Mol Biol. 45: 8539-8551. PMID: 37886981
9. Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII.  |  Kentrup, H., et al. 1996. J Biol Chem. 271: 3488-95. PMID: 8631952
10. Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from 'the Down syndrome critical region' of chromosome 21.  |  Shindoh, N., et al. 1996. Biochem Biophys Res Commun. 225: 92-9. PMID: 8769099
11. Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome 'critical region'.  |  Song, WJ., et al. 1996. Genomics. 38: 331-9. PMID: 8975710
12. Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases.  |  Becker, W., et al. 1998. J Biol Chem. 273: 25893-902. PMID: 9748265

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dyrk2 Antibody (6E2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Dyrk2 Antibody (6E2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dyrk2 Antibody (6E2) Specifications

Alternate Product Name: Dyrk2

Product Clone Name: 6E2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-100

Epitope Target: Dyrk2

Epitope Species: human

Product Reactivity/Detection: Dyrk2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Dyrk2 Antibody (6E2): N/A