demethylated-PP2A-C Activators
The class of PP2A-C activators constitutes a compelling array of chemicals that intricately modulate the phosphatase activity of PP2A, a pivotal cellular regulator involved in a myriad of signaling pathways. One noteworthy member of this class is Phosphatidic Acid (PA), a cellular lipid that exerts its activator role by influencing PP2A's subcellular localization and substrate specificity through interactions with regulatory subunits. The dynamic interplay between PA and PP2A not only emphasizes the nuanced regulation of cellular processes but also underscores the significance of lipid-protein interactions in cellular homeostasis. C2 Ceramide, another distinctive activator, indirectly stimulates PP2A-C by impacting signaling pathways upstream of PP2A. This sphingolipid derivative showcases the intricate web of cellular signaling, where alterations in lipid composition can reverberate through cascades, ultimately influencing PP2A activity. Additionally, Endothelial Nitric Oxide (NO) stands out as a modulator that activates PP2A-C through post-translational modifications.
FTY720 (Fingolimod) and Forskolin contribute to the indirect activation of PP2A-C by modulating sphingolipid metabolism and cAMP-mediated pathways, respectively. These compounds exemplify how small molecules can act as conduits, transmitting signals that culminate in the activation of PP2A and subsequent modulation of various cellular processes. Resveratrol, Thymoquinone, and 4-Hydroxytamoxifen are characterized by their indirect activation of PP2A-C, affecting cellular processes through the intricate modulation of upstream signaling pathways. On the other hand, AAL-993, Fusicoccin and ISA27 emerge as direct activators of PP2A-C, influencing cellular processes by promoting the dephosphorylation of specific substrates.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $124.00 $460.00 | 12 | |
Bioactive sphingolipid that acts as an indirect activator of PP2A-C. C2 ceramide influences signaling pathways upstream of PP2A, leading to enhanced phosphatase activity. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Sphingosine analog with indirect PP2A-C activation properties. FTY720 modulates sphingolipid metabolism, affecting PP2A activity and influencing cellular processes such as cell cycle progression and apoptosis. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activator of adenylyl cyclase, indirectly influencing PP2A-C through cAMP-mediated pathways. Forskolin activates PP2A by modulating cellular cAMP levels, impacting various signaling cascades and cellular processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenolic compound that indirectly activates PP2A-C. Resveratrol influences upstream signaling pathways, leading to enhanced PP2A phosphatase activity. This modulation affects cellular processes such as cell cycle regulation and apoptosis. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Bioactive compound found in Nigella sativa that acts as an indirect activator of PP2A-C. Thymoquinone modulates cellular redox status, influencing PP2A activity and impacting signaling pathways related to cell survival and proliferation. | ||||||
(Z)-4-Hydroxytamoxifen | 68047-06-3 | sc-3542C sc-3542 sc-3542B sc-3542A sc-3542D sc-3542E | 1 mg 5 mg 10 mg 25 mg 50 mg 100 mg | $220.00 $281.00 $408.00 $718.00 $1377.00 $2397.00 | 20 | |
Metabolite of tamoxifen that indirectly activates PP2A-C. It affects cellular signaling pathways through estrogen receptor-independent mechanisms, leading to the activation of PP2A and subsequent modulation of various cellular processes. | ||||||
Fusicoccin | 20108-30-9 | sc-200754 sc-200754A sc-200754B | 1 mg 5 mg 10 mg | $416.00 $2081.00 $4162.00 | 7 | |
Phytotoxin that serves as a direct activator of PP2A-C. Fusicoccin binds to PP2A regulatory subunits, leading to conformational changes that activate the phosphatase. This activation influences various cellular processes by modulating substrate dephosphorylation. | ||||||