CYP2W1 Activators
CYP2W1 activators are compounds that enhance the enzymatic activity of cytochrome P450 2W1, a member of the cytochrome P450 superfamily of enzymes. CYP2W1 is involved in the oxidation of various substrates, including potential endogenous compounds and xenobiotics. The role of CYP2W1 in metabolic processes is not fully understood, but like other P450 enzymes, it is presumed to be involved in the metabolism of drugs and the synthesis of cholesterol, steroids, and other lipids.
Activators of CYP2W1 may directly interact with the enzyme to increase its catalytic efficiency. This direct activation could be achieved by binding to the active site and inducing a conformational change that facilitates substrate entry or by allosteric modulation where the activator binds to a secondary site on the enzyme, altering its shape to increase the affinity or turnover rate for its substrates. These types of activators are particularly useful in research as they can help to understand the enzyme's substrate specificity and the mechanics of its catalytic cycle. Indirect activation of CYP2W1 could occur through mechanisms that increase the expression of the CYP2W1 gene, stabilize the mRNA, or enhance the translation of the enzyme. Additionally, molecules that modulate the cellular signaling pathways that control the expression of CYP2W1, such as those involved in the response to cellular stress or those that regulate the detoxification of drugs and carcinogens, could also serve as indirect activators.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can induce CYP2W1 expression through activation of the glucocorticoid receptor (GR). The activated GR can bind to glucocorticoid response elements (GREs) in the CYP2W1 gene promoter, enhancing its transcription. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampin is an antibiotic that induces CYP2W1 expression through activation of the nuclear receptor pregnane X receptor (PXR). PXR can bind to response elements in the CYP2W1 gene promoter, promoting its transcription. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole, a proton pump inhibitor, can induce CYP2W1 expression by activating the aryl hydrocarbon receptor (AhR). Activated AhR can interact with xenobiotic response elements (XREs) in the CYP2W1 gene promoter, stimulating its transcription. | ||||||
Phenylbutazone | 50-33-9 | sc-204843 | 5 g | $32.00 | 1 | |
Phenylbutazone, a non-steroidal anti-inflammatory drug (NSAID), can enhance CYP2W1 expression through activation of the peroxisome proliferator-activated receptor alpha (PPARα). Activated PPARα can bind to peroxisome proliferator response elements (PPREs) in the CYP2W1 gene promoter, increasing its transcription. | ||||||
Auraptene | 495-02-3 | sc-202477 sc-202477A | 5 mg 25 mg | $46.00 $61.00 | ||
Auraptene, a natural coumarin from citrus, can induce CYP2W1 expression by activating AhR. Activated AhR can interact with XREs in the CYP2W1 gene promoter, stimulating its transcription. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine, a bioactive compound in black pepper, can enhance CYP2W1 expression through activation of PXR. Activated PXR can bind to response elements in the CYP2W1 gene promoter, promoting its transcription. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane, an isothiocyanate found in broccoli, can induce CYP2W1 expression by activating the nuclear factor erythroid 2-related factor 2 (Nrf2). Activated Nrf2 can bind to antioxidant response elements (AREs) in the CYP2W1 gene promoter, enhancing its transcription. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
Diethylstilbestrol, a synthetic estrogen, can stimulate CYP2W1 expression via the estrogen receptor (ER). The activated ER can bind to estrogen response elements (EREs) in the CYP2W1 gene promoter, promoting its transcription. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, the active compound in chili peppers, can enhance CYP2W1 expression via the transient receptor potential vanilloid 1 (TRPV1). Activation of TRPV1 can lead to intracellular calcium influx and activation of calcium-dependent transcription factors that can bind to the CYP2W1 gene promoter, enhancing its transcription. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen from soy, can stimulate CYP2W1 expression via the ER. The activated ER can bind to EREs in the CYP2W1 gene promoter, promoting its transcription. | ||||||