Date published: 2026-6-4

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TREX-1 Antibodies

Santa Cruz Biotechnology features a diverse variety of TREX-1 monoclonal antibodies for research focused on understanding TREX-1's role in cellular processes. TREX-1 monoclonal antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). TREX-1, or three prime repair exonuclease 1, is a crucial enzyme involved in the degradation of cytosolic DNA, playing a significant role in maintaining genomic stability and preventing autoimmune responses. Its function is essential during viral infections and cellular stress, as it helps regulate the immune response by controlling DNA levels in the cytoplasm. Dysregulation of TREX-1 has been linked to various diseases, including autoimmune disorders and cancer, making it a key focus in both basic and translational research. Understanding TREX-1's molecular mechanisms can provide valuable insights into disease pathways and potential therapeutic strategies. Investigating TREX-1's cellular distribution and protein interactions can reveal new aspects of its biological functions. Research with TREX-1 monoclonal antibodies continues to advance our understanding of immune system regulation and DNA metabolism. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific knowledge and developing potential therapeutic approaches.

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TREX-1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

TREX-1 Antibody (E-6)

sc-271870mouse IgG2a κ290-369 (h)WB, IP, IF, ELISAh
11
(4)

TREX-1 Antibody (C-11)

sc-133112mouse IgG2a κ201-314 (m)WB, IP, IF, ELISAm, r
9
(5)

TREX-1 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

TREX-1 CRISPR/Cas9 KO Plasmid (h)

sc-403875hGene KnockoutGFP0
(0)

TREX-1 HDR Plasmid (h)

sc-403875-HDRhHomology Directed RepairPuromycin0
(0)

TREX-1 Double Nickase Plasmid (h)

sc-403875-NIChGene KnockoutPuromycin0
(0)

TREX-1 Double Nickase Plasmid (h2)

sc-403875-NIC-2hGene KnockoutPuromycin0
(0)

TREX-1 CRISPR/Cas9 KO Plasmid (m)

sc-423502mGene KnockoutGFP0
(0)

TREX-1 Double Nickase Plasmid (m)

sc-423502-NICmGene KnockoutPuromycin0
(0)

TREX-1 Double Nickase Plasmid (m2)

sc-423502-NIC-2mGene KnockoutPuromycin0
(0)

TREX-1 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

TREX-1 CRISPR Activation Plasmid (h)

sc-403875-ACThGene ActivationPuro, Blast, Hygro0
(0)

TREX-1 Lentiviral Activation Particles (h)

sc-403875-LAChGene ActivationPuro, Blast, Hygro0
(0)

TREX-1 CRISPR Activation Plasmid (m)

sc-423502-ACTmGene ActivationPuro, Blast, Hygro0
(0)

TREX-1 CRISPR Activation Plasmid (m2)

sc-423502-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

TREX-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

TREX-1 siRNA (h)

sc-63157hGene SilencingN/A
1
(0)

TREX-1 shRNA Plasmid (h)

sc-63157-SHhGene SilencingPuromycin
1
(0)

TREX-1 shRNA (h) Lentiviral Particles

sc-63157-VhGene SilencingPuromycin
1
(0)

TREX-1 siRNA (m)

sc-63158mGene SilencingN/A
1
(0)

TREX-1 shRNA Plasmid (m)

sc-63158-SHmGene SilencingPuromycin
1
(0)

TREX-1 shRNA (m) Lentiviral Particles

sc-63158-VmGene SilencingPuromycin
1
(0)