S-100A13 Activators
S-100A13 activators encompass a range of chemical entities that modulate the functional activity of the S-100A13 protein, a member of the S-100 protein family characterized by two distinct calcium-binding EF-hand motifs. S-100 proteins are known to be involved in a variety of intracellular and extracellular functions, including the regulation of protein phosphorylation, the dynamics of cytoskeleton constituents, calcium homeostasis, and the protection against oxidative damage. S-100A13 specifically has been implicated in the non-classical export of certain proteins from cells, a process that does not rely on the conventional secretory pathway.
Direct activators of S-100A13 may interact with the protein by binding to its calcium-binding sites or other regulatory domains, thereby altering its conformation and enhancing its affinity for target proteins or its ability to facilitate their export. Such activators might stabilize the active state of S-100A13 or promote its interaction with partner molecules that are crucial for its function in non-classical protein export. Indirect activators of S-100A13 might function by influencing the expression levels of the S-100A13 gene, leading to an increase in protein synthesis. They could also affect the stability of S-100A13 mRNA or modulate the post-translational modifications of the protein, which may include phosphorylation or acetylation, impacting its cellular localization and activity. Furthermore, indirect activators might affect the availability of calcium or other co-factors that are essential for the activation of S-100A13, thereby modulating its functional state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions can bind to S-100A13, leading to a conformational change and enhancing its functional activity. S-100A13 is known to be a calcium-binding protein and its binding with calcium is crucial for its function in the non-classical pathway of protein export. | ||||||
Copper | 7440-50-8 | sc-211129 | 100 g | $51.00 | ||
Copper ions can bind to S-100A13, leading to a conformational change and enhancing its functional activity. S-100A13 is known to be a copper-binding protein and copper binding is involved in the regulation of its function, including its role in the non-classical pathway of protein export. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in intracellular calcium levels. This increase in calcium levels can enhance the functional activity of S-100A13 due to its calcium-binding properties. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a mobile ion carrier that forms a complex with divalent cations (especially calcium) and transports them across biological membranes, leading to an increase in intracellular calcium levels. This can enhance the functional activity of S-100A13 due to its calcium-binding properties. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that allows the passage of calcium ions across biological membranes, leading to an increase in intracellular calcium levels. This can enhance the functional activity of S-100A13 due to its calcium-binding properties. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can bind to S-100A13, leading to a conformational change and enhancing its functional activity. S-100A13 is known to be a zinc-binding protein and zinc binding is involved in the regulation of its function, including its role in the non-classical pathway of protein export. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram is a drug that chelates copper and increases intracellular copper levels. This can enhance the functional activity of S-100A13 due to its copper-binding properties. | ||||||
Neocuproine | 484-11-7 | sc-257893 sc-257893A sc-257893B sc-257893C sc-257893D | 1 g 5 g 25 g 100 g 250 g | $34.00 $90.00 $297.00 $1108.00 $2388.00 | 1 | |
Neocuproine is a copper(I) chelator that increases intracellular copper levels, which can enhance the functional activity of S-100A13 due to its copper-binding properties. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
Clioquinol is a zinc and copper chelator that increases intracellular zinc and copper levels, which can enhance the functional activity of S-100A13 due to its zinc and copper-binding properties. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
D-penicillamine is a copper chelator that increases intracellular copper levels, which can enhance the functional activity of S-100A13 due to its copper-binding properties. | ||||||