IL-12Rβ1 Inhibitors
IL-12Rβ1 Inhibitors belong to a class of chemical compounds designed to target and inhibit the IL-12 receptor beta 1 subunit, also known as IL-12Rβ1. This receptor is a crucial component of the immune system, as it plays a central role in the signaling pathways that regulate the immune response. IL-12Rβ1 is a transmembrane protein found on the surface of various immune cells, including T cells and natural killer (NK) cells. When activated, it participates in the signaling cascade that leads to the activation of these immune cells and the production of pro-inflammatory cytokines.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Inhibits calcineurin after binding to cyclophilin, which can suppress IL-12 signaling by reducing T-cell activation. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Binds to FKBP12, forming a complex that inhibits calcineurin, thereby reducing IL-2 production and downstream effects on IL-12 signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Binds to FKBP12 but inhibits mTOR, which can modulate T-cell proliferation and indirectly influence IL-12 signaling. | ||||||
Ascomycin | 104987-12-4 | sc-207303B sc-207303 sc-207303A | 1 mg 5 mg 25 mg | $37.00 $176.00 $322.00 | ||
Acts similarly to tacrolimus in inhibiting calcineurin after binding to FKBP12, affecting T-cell activation and IL-12 responses. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Prevents lymphocyte egress from lymph nodes, reducing immune responses including IL-12 mediated signaling. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibits NF-κB, a transcription factor downstream of IL-12 signaling, leading to reduced cytokine production. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Inhibits c-Kit and other kinases, which can affect the differentiation of cells that participate in IL-12 signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits PI3K, affecting signaling pathways downstream of IL-12 and its receptor. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Inhibits MEK, which is upstream of ERK in the MAPK pathway, affecting the response to IL-12 signaling. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $58.00 $204.00 | 15 | |
Inhibits STAT1 phosphorylation, which is critical for IL-12 signaling through its receptor. | ||||||