IL-12Rβ1 Antibody (A-10): sc-166776
- IL-12Rβ1 Antibody (A-10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-300 of IL-12Rβ1 of human origin
- recommended for detection of IL-12Rβ1 of human origin by WB, IP, IF and ELISA
- Anti-IL-12R beta 1 Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IL-12Rβ1 Antibody (A-10) for WB applications. These reagents are now offered in bundles with IL-12Rβ1 Antibody (A-10) (see ordering information below).
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IL-12Rβ1 Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-12Rβ1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-12Rβ1 (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-12Rβ1 plays a critical role in immune response by serving as a receptor for interleukin-12 (IL-12), a key cytokine that influences differentiation and activation of T cells and natural killer (NK) cells. IL-12Rβ1 is essential for mediating IL-12 effects, which include stimulation of interferon-gamma production and enhancement of cytotoxic activity in immune cells. Proper functioning of IL-12Rβ1 is vital for maintaining a balanced immune response; dysregulation can lead to pathological conditions such as autoimmune diseases or impaired immune responses. Genes encoding IL-12Rβ1 and IL-12Rβ2 are located on chromosomes 19p13.1 and 1p31.3, respectively, highlighting their genetic significance in immune regulation. Understanding IL-12Rβ1′s role in immune signaling pathways can provide insights into therapeutic strategies for diseases characterized by abnormal Th1 responses, making anti-IL-12Rβ1 antibody (A-10) a valuable tool for researchers studying immune function and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-12Rβ1 Antibody (A-10) References:
- Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease. | Parrello, T., et al. 2000. J Immunol. 165: 7234-9. PMID: 11120856
- Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. | Wolf, SF., et al. 1991. J Immunol. 146: 3074-81. PMID: 1673147
- Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. | Gubler, U., et al. 1991. Proc Natl Acad Sci U S A. 88: 4143-7. PMID: 1674604
- Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. | Manetti, R., et al. 1993. J Exp Med. 177: 1199-204. PMID: 8096238
- Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization. | Yamamoto, K., et al. 1997. Cytogenet Cell Genet. 77: 257-8. PMID: 9284929
- The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. | Gately, MK., et al. 1998. Annu Rev Immunol. 16: 495-521. PMID: 9597139
- Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunit. | Kawashima, T., et al. 1998. Cell Immunol. 186: 39-44. PMID: 9637763
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-12Rβ1 Antibody (A-10) | sc-166776 | 200 µg/ml | $322.00 | |||
IL-12Rβ1 Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-540158 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-12Rβ1 Antibody (A-10): m-IgG1 BP-HRP Bundle | sc-541939 | 200 µg Ab; 20 µg BP | $361.00 | |||
IL-12Rβ1 Antibody (A-10) AC | sc-166776 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IL-12Rβ1 Antibody (A-10) HRP | sc-166776 HRP | 200 µg/ml | $322.00 | |||
IL-12Rβ1 Antibody (A-10) FITC | sc-166776 FITC | 200 µg/ml | $336.00 | |||
IL-12Rβ1 Antibody (A-10) PE | sc-166776 PE | 200 µg/ml | $349.00 | |||
IL-12Rβ1 Antibody (A-10) Alexa Fluor® 488 | sc-166776 AF488 | 200 µg/ml | $364.00 | |||
IL-12Rβ1 Antibody (A-10) Alexa Fluor® 546 | sc-166776 AF546 | 200 µg/ml | $364.00 | |||
IL-12Rβ1 Antibody (A-10) Alexa Fluor® 594 | sc-166776 AF594 | 200 µg/ml | $364.00 | |||
IL-12Rβ1 Antibody (A-10) Alexa Fluor® 647 | sc-166776 AF647 | 200 µg/ml | $364.00 | |||
IL-12Rβ1 Antibody (A-10) Alexa Fluor® 680 | sc-166776 AF680 | 200 µg/ml | $364.00 | |||
IL-12Rβ1 Antibody (A-10) Alexa Fluor® 790 | sc-166776 AF790 | 200 µg/ml | $364.00 |