CatSperγ Inhibitors
CatSperγ inhibitors exhibit a wide array of mechanisms by which they achieve the functional inhibition of the CatSperγ protein, each interacting with different cellular components and pathways. Substances like niflumic acid and flufenamic acid act on ion channels, altering the ionic currents and concentrations that are essential for the proper functioning of CatSperγ. By modifying the electrochemical gradient, they indirectly affect the channel's activity, which is critical for calcium signaling in sperm cells.
Compounds such as ketoconazole and clotrimazole take a different approach by targeting steroid biosynthesis. By inhibiting enzymes responsible for producing steroids, they reduce the levels of these hormones that are known to modulate CatSperγ. The reduced hormonal stimulation leads to a decrease in the channel's activity, affecting sperm motility and the capacity for fertilization.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic acid, a nonsteroidal anti-inflammatory drug (NSAID), inhibits the activity of phospholipase A2, leading to a decrease in arachidonic acid release and subsequent prostaglandin synthesis. By reducing the levels of prostaglandins, which can modulate ion channel activity, it indirectly inhibits the CatSperγ channel activity by reducing the modulation potential. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $213.00 $865.00 | 4 | |
Mibefradil is a T-type calcium channel blocker that can indirectly inhibit CatSperγ by reducing the intracellular calcium concentration. Since CatSper channels are calcium-sensitive, their activity can be indirectly reduced by modulating the intracellular calcium levels through T-type channels inhibition. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an L-type calcium channel blocker that indirectly inhibits CatSperγ function by decreasing overall cellular calcium influx. With lowered calcium levels, the CatSper channels, which are calcium-activated, would have less activation and thus reduced function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can inhibit CatSper channels by binding to the extracellular part of the channel and altering its conformation. Zinc sulfate, as a source of zinc ions, can thus indirectly inhibit CatSperγ activity by making the channel less responsive to calcium ions, which are necessary for its activation. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $63.00 $265.00 | 21 | |
Ketoconazole, an antifungal agent, inhibits cytochrome P450 enzymes and thus can reduce the synthesis of steroid hormones. Since CatSperγ is known to be activated by certain steroids, ketoconazole's action in reducing these activating hormones would result in an indirect inhibition of CatSperγ activity. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole is another inhibitor of cytochrome P450 enzymes, which leads to a decrease in steroid synthesis. Because CatSperγ activity is modulated by hormonal levels, specifically steroids, clotrimazole indirectly inhibits CatSperγ by reducing the synthesis of its activators. | ||||||
Nickel(II) chloride | 7718-54-9 | sc-236169 sc-236169A | 100 g 500 g | $68.00 $188.00 | ||
Nickel chloride (NiCl2) can inhibit CatSper channels by binding to specific sites on the channel, leading to reduced calcium influx. This inhibition of calcium flow indirectly reduces the activity of CatSperγ, as it relies on calcium ions for its function. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride is known to block certain ion channels including sodium channels and has been shown to inhibit CatSper channels indirectly. By altering the intracellular ionic environment, particularly sodium, amiloride can diminish the driving force for calcium entry through CatSperγ, thus indirectly inhibiting its activity. | ||||||
Clofilium tosylate | 92953-10-1 | sc-391228 sc-391228A | 25 mg 100 mg | $437.00 $1040.00 | 1 | |
Clofilium tosylate is a potassium channel blocker that can indirectly inhibit CatSperγ activity by affecting the membrane potential. A more depolarized membrane potential due to blocked potassium channels can reduce the driving force for calcium entry through CatSper channels. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
Flufenamic acid is a member of the fenamate group of NSAIDs and has been shown to block various ion channels. It has the ability to inhibit CatSper channels, therefore indirectly inhibiting CatSperγ by reducing the calcium influx that is essential for its activation. | ||||||