CatSperγ Activators
CatSperγ can play significant roles in regulating the protein's activity, particularly in the context of sperm motility. Progesterone, a steroid hormone, has an established connection to CatSperγ activation. It binds to its receptor and induces a cascade that increases intracellular calcium concentration, which is crucial for CatSperγ's role in sperm motility. Similarly, 4-Aminopyridine, as a potassium channel blocker, prolongs action potentials, leading to an augmented calcium influx and activation of CatSperγ. Zinc, as a vital trace element, interacts with CatSper channels directly, modulating their activity, and it is integral for sperm hyperactivation. Estradiol, through estrogen receptor-mediated actions, can influence intracellular calcium levels, thus affecting the functionality of calcium channels like CatSperγ.
Other activators work through secondary messenger systems. Forskolin targets adenylyl cyclase, subsequently raising cyclic AMP levels, which activate protein kinase A. PKA then phosphorylates various proteins, including those that modulate ion channels such as CatSperγ. Genistein and caffeine both elevate cAMP by inhibiting phosphodiesterases, leading to the activation of PKA and subsequent phosphorylation and activation of CatSperγ. Glycine acts as a co-agonist at receptors that regulate calcium channels, enhancing calcium influx and CatSperγ activation. L-Arginine is metabolized to produce nitric oxide, which increases cGMP, activating PKG that can also phosphorylate and activate CatSperγ. Taurine affects calcium homeostasis, which is pivotal for CatSperγ activity in sperm cells. Veratridine, by activating sodium channels, leads to membrane depolarization, which can subsequently activate voltage-gated calcium channels and potentially CatSperγ. Finally, niflumic acid, by blocking chloride channels, alters ionic balances, indirectly affecting calcium channel function and potentially leading to the activation of CatSperγ. Each of these chemicals, through their distinct mechanisms, ensures the proper functioning and activation of CatSperγ, facilitating its role in sperm physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone, a steroid hormone, activates CatSperγ by binding to a receptor that indirectly causes an increase in intracellular calcium concentration, which is necessary for CatSperγ function related to sperm motility. | ||||||
4-Aminopyridine | 504-24-5 | sc-202421 sc-202421B sc-202421A | 25 g 1 kg 100 g | $37.00 $1132.00 $120.00 | 3 | |
4-Aminopyridine is a potassium channel blocker that increases the duration of action potentials, leading to enhanced calcium influx which in turn can activate CatSperγ by promoting the required calcium-dependent processes in sperm cells. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions can modulate sperm motility by directly affecting the CatSperγ channel’s activity, as zinc has been suggested to interact with CatSper channels and is important for the hyperactivation of sperm. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol, through its receptor-mediated action, can cause changes in sperm intracellular environment that activates CatSperγ by altering ion channel permeability and affecting calcium signaling in sperm. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase leading to an increase in cyclic AMP levels, which can stimulate protein kinase A (PKA) to phosphorylate targets that modulate calcium channels activity including CatSperγ. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can increase intracellular cAMP by inhibiting phosphodiesterases, which in turn activates PKA that is known to phosphorylate and activate ion channels like CatSperγ. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels which can enhance PKA activity, subsequently phosphorylating and activating CatSperγ channels. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $40.00 $70.00 $110.00 $350.00 | 15 | |
Glycine can serve as a co-agonist at certain receptors that regulate calcium channels, thereby potentially enhancing calcium influx and activating CatSperγ. | ||||||
L-Arginine | 74-79-3 | sc-391657B sc-391657 sc-391657A sc-391657C sc-391657D | 5 g 25 g 100 g 500 g 1 kg | $20.00 $30.00 $60.00 $215.00 $345.00 | 2 | |
L-Arginine serves as a substrate for nitric oxide synthase, leading to the production of nitric oxide which can increase intracellular cGMP, activating protein kinase G (PKG) that can phosphorylate and activate channels like CatSperγ. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $47.00 $100.00 | 1 | |
Taurine is known to affect cell volume regulation and calcium homeostasis, which can lead to the activation of calcium channels including CatSperγ, particularly in the context of sperm hyperactivation. | ||||||