ADAMTS-10 Aktivatoren
ADAMTS-10 (A Disintegrin And Metalloproteinase with Thrombospondin Motifs 10) is a member of the ADAMTS family of extracellular proteases, characterized by their zinc-dependent metalloproteinase and thrombospondin type 1 motif domains. ADAMTS-10 is primarily expressed in various tissues during embryonic development and plays crucial roles in extracellular matrix (ECM) remodeling, tissue morphogenesis, and cell migration. Functionally, ADAMTS-10 contributes to tissue homeostasis by regulating the turnover and organization of ECM components, including proteoglycans, collagen, and elastin. Its proteolytic activity enables the cleavage of ECM proteins, leading to structural modifications that influence cell behavior and tissue architecture. Additionally, ADAMTS-10 has been implicated in diverse physiological processes such as angiogenesis, wound healing, and skeletal development, highlighting its significance in both normal development and pathological conditions.
Activation of ADAMTS-10 is regulated by various mechanisms that control its enzymatic activity and substrate specificity. Post-translational modifications, such as glycosylation and proteolytic processing, can modulate ADAMTS-10 activity by affecting its stability, localization, and interaction with ECM substrates. Furthermore, interactions with other proteins and signaling molecules within the ECM microenvironment can regulate ADAMTS-10 function. For instance, binding of ECM proteins or cell surface receptors can induce conformational changes in ADAMTS-10, facilitating its activation and substrate recognition. Additionally, signaling pathways such as the MAPK/ERK pathway and the TGF-β signaling cascade have been implicated in the regulation of ADAMTS-10 expression and activity. Activation of these pathways can modulate ADAMTS-10 transcription, translation, or post-translational modifications, thereby influencing its proteolytic function and biological activity. Overall, the multifaceted regulation of ADAMTS-10 activation underscores its importance in ECM dynamics and tissue homeostasis, with implications for various physiological and pathological processes.
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| Produkt | CAS # | Katalog # | Menge | Preis | Referenzen | Bewertung |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β-Inhibitoren wie SB431542 können ADAMTS-10 indirekt aktivieren, indem sie dessen Herunterregulierung verhindern, da die TGF-β-Signalübertragung normalerweise die ADAMTS-10-Expression unterdrückt. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
HDAC-Inhibitoren wie Vorinostat können möglicherweise ADAMTS-10 aktivieren, indem sie die epigenetische Regulation modulieren, was zu einer verstärkten Genexpression, einschließlich der von ADAMTS-10, führt. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Substanzen, die die Kollagensynthese hemmen, wie Ascorbinsäure, können ADAMTS-10 indirekt aktivieren, indem sie die Verfügbarkeit von Kollagensubstraten verringern und damit seine Aktivität beeinträchtigen. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $75.00 $265.00 | 55 | |
MMP-Inhibitoren wie GM6001 können ADAMTS-10 indirekt aktivieren, indem sie den Abbau von ECM-Komponenten verhindern und so Substrate für die Wirkung von ADAMTS-10 verfügbar halten. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Nrf2-Aktivatoren wie Sulforaphan können möglicherweise ADAMTS-10 aktivieren, indem sie die zelluläre antioxidative Reaktion verstärken, was die Aktivität von ADAMTS-10 unter oxidativem Stress beeinflussen kann. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $82.00 $295.00 $367.00 $764.00 | 25 | |
Hydroxylase-Inhibitoren wie Dimethyloxalylglycin können ADAMTS-10 möglicherweise aktivieren, indem sie posttranslationale Modifikationen modulieren und seine Stabilität oder Aktivität beeinflussen. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
ROS-Scavenger wie N-Acetylcystein können ADAMTS-10 indirekt aktivieren, indem sie oxidativen Stress reduzieren, was sich auf seine Aktivität in einer oxidativen extrazellulären Umgebung auswirken kann. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
Modulatoren der Notch-Signalübertragung wie DAPT können sich möglicherweise auf ADAMTS-10 auswirken, indem sie die Zell-Zell-Kommunikationswege verändern, was seine Expression oder Aktivität beeinflussen kann. | ||||||