ZSCAN1 Inhibitors
Chemical inhibitors of ZSCAN1 operate through diverse mechanisms to impede its function in transcriptional regulation. Palbociclib targets the cell cycle machinery, specifically inhibiting CDK4/6, which are crucial for cell cycle progression through the G1 phase. The inhibition of CDK4/6 limits the proliferation of cells, thereby reducing the overall activity of ZSCAN1 due to its role in cell cycle-dependent transcriptional regulation. Similarly, PF-06821497, a CDK9 inhibitor, impairs RNA polymerase II's transcription elongation capability, which is necessary for ZSCAN1's transcriptional regulation, leading to an overall decrease in its transcriptional activity.
Furthermore, several inhibitors target the epigenetic modulators that ZSCAN1 interacts with to regulate transcription. For instance, RGFP966, an HDAC3 inhibitor, leads to changes in chromatin structure by increasing histone acetylation, which can interfere with ZSCAN1's ability to bind to DNA and modulate gene expression. Trichostatin A and SAHA (Vorinostat) also inhibit HDACs, leading to hyperacetylation of histones, which can prevent ZSCAN1 from effectively interacting with chromatin, thus impeding its regulatory functions. Entinostat and MS-275 further contribute to this mechanism by inhibiting HDAC1/3, altering the chromatin landscape and potentially impairing ZSCAN1's DNA binding and transcriptional repression activities.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Palbociclib is a CDK4/6 inhibitor that can inhibit ZSCAN1 by restricting the cell cycle progression at the G1 phase, which is essential for ZSCAN1's role in transcriptional regulation. | ||||||
RGFP966 | 1357389-11-7 | sc-507300 | 5 mg | $115.00 | ||
RGFP966 is an HDAC3 inhibitor; by inhibiting HDAC3, it can alter the chromatin structure and thus inhibit ZSCAN1's ability to bind DNA and regulate gene expression. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that can inhibit ZSCAN1 by disrupting the interaction between BET bromodomains and acetylated histones, potentially impairing ZSCAN1's function in chromatin remodeling and transcriptional regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an HDAC inhibitor that can lead to hyperacetylation of histones, possibly inhibiting ZSCAN1's ability to interact with chromatin and thus its function in gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is an HDAC inhibitor that can hyperacetylate histones, which may inhibit ZSCAN1's DNA binding activity and its role in transcriptional regulation. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Entinostat is an HDAC1/3 inhibitor that, by altering acetylation levels of histones, can inhibit the transcriptional regulatory functions of ZSCAN1. | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
GSK126 is an EZH2 methyltransferase inhibitor that can reduce histone H3K27 methylation, a modification that ZSCAN1 may utilize for transcriptional repression, thus inhibiting its function. | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is a selective inhibitor of EZH2 and EZH1 that can inhibit the methylation of histone H3 on lysine 27, potentially disrupting ZSCAN1 function in transcriptional repression. | ||||||
EPZ6438 | 1403254-99-8 | sc-507456 | 1 mg | $66.00 | ||
EPZ-6438 is an EZH2 inhibitor that can reduce H3K27me3 levels, possibly inhibiting ZSCAN1's role in transcriptional repression by affecting chromatin compaction. | ||||||