ZNF878 Activators
Chemical activators of ZNF878 include a variety of compounds that enhance its functional state through different biochemical pathways. Zinc Sulfate is a direct activator, providing zinc ions that are crucial for the structural integrity and proper folding of ZNF878, which possesses zinc finger motifs. This stabilization is requisite for the activation of ZNF878, ensuring that it can interact with other molecules effectively. Sodium Fluoride maintains ZNF878's phosphorylation status by inhibiting phosphatases, leading to activation. Forskolin, by raising intracellular cAMP levels, activates protein kinase A (PKA), which can phosphorylate ZNF878, a post-translational modification vital for its activation. Ionomycin, through the increase of intracellular calcium, activates calcium-dependent kinases that can phosphorylate and activate ZNF878.
Further, Phorbol 12-myristate is another activator that stimulates protein kinase C (PKC), which can phosphorylate ZNF878 and signal its activation. Calyculin A and Okadaic Acid both inhibit the action of protein phosphatases, thus preventing the dephosphorylation of ZNF878, maintaining its active phosphorylated state. Anisomycin activates stress-activated protein kinases (SAPKs), which are capable of phosphorylating ZNF878, leading to its activation. Thapsigargin also raises intracellular calcium levels and activates kinases that phosphorylate ZNF878, a necessary step for its activation. Retinoic Acid modulates signaling pathways involving kinases that can activate ZNF878 through phosphorylation. Bisindolylmaleimide I, despite being a PKC inhibitor, can paradoxically activate alternative kinases that may target ZNF878 for activation. Lastly, Magnesium Chloride provides magnesium ions that can stabilize ZNF878's structure and enhance interactions with enzymatic cofactors or structural domains necessary for its activation. Each of these chemicals ensures that ZNF878 is maintained in an active state through phosphorylation or structural stabilization, enabling it to function properly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc Sulfate provides zinc ions that can directly interact with zinc finger motifs of ZNF878, leading to proper folding and structural stability which is essential for the activation of ZNF878. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $40.00 $46.00 $100.00 | 26 | |
Sodium Fluoride acts as a phosphatase inhibitor, maintaining ZNF878 in a phosphorylated state. Since phosphorylation is a common post-translational modification that regulates protein function, inhibition of dephosphorylation leads to the activation of ZNF878. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, leading to the activation of calcium-dependent kinases. These kinases can phosphorylate ZNF878, resulting in its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Phorbol 12-myristate activates protein kinase C (PKC), which can lead to the phosphorylation of ZNF878, a modification that signals its activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases that dephosphorylate ZNF878, ensuring that ZNF878 remains in an activated, phosphorylated state. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid functions similarly to Calyculin A as an inhibitor of protein phosphatases, preventing dephosphorylation of ZNF878, thus maintaining its active state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates stress-activated protein kinases (SAPKs), which can phosphorylate ZNF878, activating the protein. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin elevates intracellular calcium levels, which activates kinases that can phosphorylate ZNF878, leading to its activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid modulates signaling pathways that include activation of kinases. These kinases can phosphorylate ZNF878, contributing to its activation. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I, although primarily a PKC inhibitor, can activate alternative kinases within the cell that might target ZNF878 for phosphorylation and subsequent activation. | ||||||