ZNF845 Inhibitors
Chemical inhibitors of ZNF845 target various signaling pathways and kinases that are essential for the protein's functional activity. Staurosporine, a well-known protein kinase inhibitor, prevents the phosphorylation of ZNF845 by inhibiting the kinases responsible for its activation. Similarly, LY294002 and wortmannin, both phosphoinositide 3-kinase (PI3K) inhibitors, suppress downstream signaling that is necessary for the functional activity of ZNF845. By halting PI3K activity, these inhibitors ensure that ZNF845 remains inactive. PD98059 and U0126, both inhibitors of mitogen-activated protein kinase kinase (MEK), block the MAPK/ERK pathway, further preventing the phosphorylation and activation of ZNF845. The JNK inhibitor SP600125 follows a similar rationale; by inhibiting JNK, it indirectly prevents the activation of ZNF845, which may rely on JNK-mediated signaling for its function.
Additional mechanisms involve p38 MAP kinase and mTOR pathways, where SB203580 and rapamycin play their roles. SB203580 specifically inhibits p38 MAP kinase, a pathway that can influence the activity of various transcription factors, including ZNF845. Rapamycin, an mTOR inhibitor, disrupts a central pathway that can regulate the functional state of ZNF845. The PKC inhibitors GF109203X, Go6983, and Ro-31-8220, by preventing PKC-mediated signaling, contribute to the inhibition of ZNF845 activity since PKC is known to modulate the function of a wide array of proteins. Lastly, lestaurtinib, a tyrosine kinase inhibitor, can inhibit the phosphorylation of ZNF845, thus ensuring that the protein remains in an inactive state.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. ZNF845's function relies on phosphorylation by specific kinases. Staurosporine inhibits these kinases, therefore preventing the phosphorylation and subsequent functional activation of ZNF845. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinases (PI3K) inhibitor. PI3K signaling can regulate the activity of a broad range of proteins including ZNF845. By inhibiting PI3K, LY294002 can suppress the downstream signaling necessary for ZNF845's functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. ZNF845's activity can be regulated by this pathway, hence PD98059 inhibits the functional activity of ZNF845 by blocking MEK. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). JNK pathway is involved in the regulation of a variety of proteins, including ZNF845. By inhibiting JNK, SP600125 can inhibit the functional activity of ZNF845. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. p38 MAP kinase pathway can influence the function of various transcription factors, including ZNF845. SB203580 inhibits the kinase, thereby inhibiting the functional activity of ZNF845. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. The mTOR pathway is crucial for many cellular processes, and mTOR's activity can influence the function of proteins including ZNF845. Rapamycin inhibits mTOR, leading to inhibition of ZNF845's function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. PI3K plays a role in regulating the function of numerous proteins, and its inhibition by wortmannin leads to a decrease in ZNF845 functional activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF109203X is an inhibitor of protein kinase C (PKC). PKC is involved in the regulation of various proteins, and its inhibition by GF109203X can lead to the inhibition of ZNF845's functional activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK, part of the MAPK/ERK pathway. By inhibiting MEK, U0126 prevents the activation of downstream proteins, leading to the inhibition of ZNF845's functional activity within this pathway. | ||||||
Lestaurtinib | 111358-88-4 | sc-218657 sc-218657A sc-218657B | 1 mg 5 mg 10 mg | $275.00 $326.00 $612.00 | 3 | |
Lestaurtinib is a tyrosine kinase inhibitor, which could inhibit kinases that phosphorylate ZNF845, thus preventing its functional activation. | ||||||