ZNF764, a member of the zinc finger protein family, serves as a transcription factor involved in the intricate regulation of gene expression and the modulation of various cellular processes. The primary function of ZNF764 lies in its ability to bind to specific DNA sequences through its zinc finger motifs, thereby modulating the transcriptional activity of target genes. Through its DNA-binding capacity, ZNF764 exerts control over diverse biological processes including development, differentiation, and cell cycle regulation. Moreover, ZNF764 has been implicated in apoptotic signaling pathways and DNA repair mechanisms, underscoring its crucial role in maintaining cellular homeostasis and integrity.
The activation of ZNF764 involves complex regulatory mechanisms that govern its expression, post-translational modifications, and interactions with other proteins and regulatory molecules. Transcriptional regulation plays a fundamental role in activating ZNF764, with various signaling pathways and transcription factors influencing its gene expression in response to cellular stimuli or environmental cues. Additionally, post-translational modifications such as phosphorylation or acetylation may regulate the activity or stability of ZNF764, thereby modulating its DNA-binding affinity and transcriptional activity. Furthermore, the recruitment of ZNF764 to specific genomic loci, facilitated by protein-protein interactions or chromatin remodeling complexes, may enhance its transcriptional activity and contribute to the regulation of target gene expression. Elucidating the precise mechanisms underlying ZNF764 activation will provide valuable insights into its physiological roles and potential implications in development, disease, and cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin stimulates the production of cAMP, which can activate PKA. PKA, in turn, can phosphorylate a variety of proteins involved in the same signaling pathways as ZNF764, leading to its enhanced activity. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
cAMP, a secondary messenger, can directly activate Protein Kinase A (PKA). Following activation, PKA can phosphorylate proteins involved in similar pathways as ZNF764, enhancing its functional activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, which break down cAMP. By inhibiting these enzymes, IBMX raises the levels of cAMP, which can activate PKA to enhance ZNF764 activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. It can activate PKA which can phosphorylate proteins that are functionally linked with ZNF764, thus enhancing its activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent and selective inhibitor of Protein Kinase A (PKA). By inhibiting PKA activity, H-89 can indirectly enhance the activity of ZNF764 through modulation of signaling events involving PKA. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. It can inhibit PKA, leading to an indirect increase in ZNF764 activity through altered phosphorylation states. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, which can dampen the Akt pathway. A decrease in Akt activity can enhance the activity of ZNF764. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor which can decrease Akt activity, leading to enhanced ZNF764 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, which can lead to decreased Akt activity. This decrease can indirectly enhance ZNF764 activity. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
BEZ235 inhibits both PI3K and mTOR, leading to decreased Akt activity and enhanced ZNF764 activity. | ||||||