ZNF618 Inhibitors
ZNF618 belongs to the diverse family of zinc finger proteins. While specific inhibitors tailored to ZNF618 are yet to be elucidated, there exists a range of compounds that can impede the function of zinc finger proteins by manipulating the availability or binding of their central component, zinc. The essential nature of zinc to these proteins means that chelation or sequestration of this metal can lead to altered functionality.
Disulfiram and Clioquinol, for instance, are known to chelate zinc, impinging on the correct configuration and functionality of zinc finger domains. The powerful zinc chelator TPEN operates in a similar manner, sequestering zinc and thereby altering the landscape for proteins that rely on it. Pyrithione acts differently as a zinc ionophore, disturbing zinc homeostasis within the cell, which could lead to downstream impacts on zinc finger proteins, including ZNF618. Meanwhile, compounds like 8-hydroxyquinoline, Dithizone, and Quercetin, renowned for their metal-chelating properties, may influence zinc finger proteins by sequestering zinc. In a broader perspective, strong chelators like EDTA, Deferoxamine, DTPA, and Dimercaprol, while not exclusive to zinc, may still affect its cellular levels and thereby the proteins that depend on it.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Chelates zinc, potentially disrupting the function of zinc finger proteins. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
Metal ion chelator that can bind to zinc, affecting zinc finger proteins. | ||||||
Dithizone | 60-10-6 | sc-206031A sc-206031 | 10 g 50 g | $92.00 $339.00 | 2 | |
Chelates metal ions including zinc, potentially influencing zinc finger protein functions. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Flavonoid that can chelate metal ions including zinc. | ||||||
Phytic acid solution | 83-86-3 | sc-205806 sc-205806A | 100 ml 500 ml | $151.00 $515.00 | ||
Known to chelate metal ions; could affect zinc finger protein function by chelating zinc. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $255.00 | ||
Iron chelator that can also chelate other metals and possibly influence zinc finger proteins. | ||||||
Diethylenetriaminepentaacetic acid | 67-43-6 | sc-214890 sc-214890A | 5 g 50 g | $75.00 $234.00 | 1 | |
Chelates metal ions; potential to influence zinc finger proteins. | ||||||