ZNF592 Inhibitors
Chemical inhibitors of ZNF592 act through various pathways to inhibit its function. Chelerythrine, targeting protein kinase C (PKC), can reduce the phosphorylation state of proteins within the PKC pathway, leading to a functional inhibition of ZNF592. Similarly, Y-27632, by inhibiting Rho-associated, coiled-coil containing protein kinase (ROCK), can impede cellular processes necessary for ZNF592's role in cell shape, motility, and contraction. PD98059 and U0126, both MEK inhibitors, can prevent the activation of the MAPK/ERK pathway, potentially leading to a decrease in ZNF592 activity by hindering necessary phosphorylation and activation. LY294002 and Wortmannin, as PI3K inhibitors, can suppress the activation of AKT, thereby impacting ZNF592 if it is regulated by the PI3K/AKT pathway.
Further, SB203580, a p38 MAP kinase inhibitor, can disrupt stress response signaling pathways that may be required for ZNF592's function. SP600125, an inhibitor of JNK, can block signaling involved in apoptosis and inflammation, which can lead to functional inhibition of ZNF592. KN-93, which targets CaMKII, can inhibit necessary calcium signaling pathways that may be crucial for ZNF592 activity. PD173074, an FGFR inhibitor, can disrupt the receptor's downstream signaling, which could be necessary for ZNF592's function. Rapamycin, an mTOR inhibitor, can disrupt signaling in the PI3K/AKT/mTOR pathway, potentially impacting ZNF592. Lastly, PP2, an inhibitor of Src family kinases, can impede signaling that regulates cell proliferation and differentiation, possibly leading to the inhibition of ZNF592 activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
Chelerythrine is a selective inhibitor of protein kinase C (PKC), which is involved in numerous cellular processes, including those that may regulate the activity of ZNF592. By inhibiting PKC, chelerythrine could reduce the phosphorylation state of proteins within the PKC pathway, potentially leading to a functional inhibition of ZNF592. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK (Rho-associated, coiled-coil containing protein kinase). ROCK has been implicated in a wide range of cellular functions that could be related to the activity of ZNF592, including cell shape, motility, and contraction. By inhibiting ROCK, Y-27632 could impede cellular processes that are necessary for ZNF592 to exert its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor, which impedes the MAPK/ERK pathway. ZNF592's activity could be regulated by ERK-mediated signaling, and thus, inhibiting MEK could result in the functional inhibition of ZNF592 by preventing its potential phosphorylation and activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of PI3K, which is a part of the PI3K/AKT pathway, a crucial signal transduction system that controls various aspects of cell survival and proliferation. Inhibition of PI3K can lead to a decrease in AKT activation, potentially impacting the activity of ZNF592 if it is regulated by this pathway. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 specifically inhibits p38 MAP kinase, which is involved in response to stress stimuli and cytokine production. This inhibitor could disrupt signaling pathways that may be required for ZNF592's activity, leading to its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which influences cellular processes such as apoptosis and inflammation. By blocking JNK signaling, SP600125 could functionally inhibit ZNF592 if the protein's activity is modulated by JNK-mediated pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is another MEK inhibitor that prevents the activation of MAPK/ERK. Inhibition of this pathway can lead to a lack of necessary phosphorylation events that may regulate the activity of ZNF592. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. By inhibiting PI3K, it can suppress AKT activation and subsequent downstream signaling that may be crucial for the functional activity of ZNF592. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of CaMKII (calcium/calmodulin-dependent protein kinase II). If ZNF592 requires CaMKII for its activity, inhibition by KN-93 could result in functional inhibition of ZNF592 by blocking necessary calcium signaling pathways. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is an FGFR (Fibroblast Growth Factor Receptor) inhibitor. If ZNF592 is functionally associated with FGFR-mediated pathways, its inhibition by PD173074 would disrupt downstream signaling necessary for the functional activity of ZNF592. | ||||||