ZNF499 Activators
ZNF499, a member of the zinc finger protein family, is characterized by the presence of zinc finger domains that facilitate DNA binding and play a pivotal role in transcriptional regulation. Although the precise biological functions of ZNF499 remain an area of active investigation, zinc finger proteins are known to be key players in various biological processes, including DNA recognition, RNA packaging, transcription activation, regulation of apoptosis, protein folding, and assembly. As transcription factors, these proteins can bind to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA. The expression of ZNF499, like many genes, is subject to regulation by a complex interplay of intracellular signals and extracellular substances, which can either enhance or suppress its activity within the cell.
Research into the regulation of gene expression has identified a diverse array of chemicals that can serve as activators, with the potential to induce the expression of genes such as ZNF499. These activators can include small molecules that interact with cellular receptors and signaling pathways, leading to upregulation of target genes. For instance, compounds like 5-Aza-2'-deoxycytidine and Trichostatin A target the epigenetic machinery, reversing DNA methylation and modifying histone acetylation, respectively, to promote gene expression. Other molecules, such as Retinoic acid and Beta-estradiol, bind to their respective receptors, triggering a cascade of transcriptional activity that can culminate in the upregulation of genes. Forskolin, by increasing intracellular cAMP levels, activates protein kinase A (PKA) and subsequently influences transcription factor activity to stimulate gene expression. Such activators operate through diverse mechanisms, each contributing to the intricate regulatory network that dictates gene expression patterns, including that of ZNF499. Understanding these mechanisms offers insights into the fundamental processes governing cellular function and gene expression regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
May upregulate ZNF499 by removing methyl groups from the DNA within its promoter region, thus facilitating the binding of transcription factors that stimulate gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Could potentially enhance ZNF499 transcription by preventing the deacetylation of histones, thereby maintaining an open chromatin structure conducive to gene activation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Might activate ZNF499 expression by increasing histone acetylation levels, which can lead to the recruitment of transcriptional machinery to the ZNF499 gene locus. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Could stimulate ZNF499 expression through activation of retinoic acid receptors, leading to transcriptional activation of genes with retinoic acid-responsive elements. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
May increase ZNF499 expression by catalyzing the conversion of ATP to cAMP, which then activates a cascade leading to the phosphorylation and activation of transcription factors. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Might upregulate ZNF499 through binding to estrogen receptors that interact with estrogen response elements on the ZNF499 gene promoter, stimulating gene transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Could induce ZNF499 expression by binding to glucocorticoid receptors that may interact with glucocorticoid response elements in the ZNF499 promoter, promoting gene activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
May stimulate ZNF499 expression by inhibiting histone deacetylases, leading to an open chromatin state that facilitates the transcription of ZNF499. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Could upregulate ZNF499 by altering intracellular signaling cascades, such as the Wnt signaling pathway, which can lead to changes in gene transcription patterns. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $61.00 | 17 | |
Might stimulate ZNF499 by blocking glucocorticoid receptors, potentially reversing the repression of ZNF499 expression in tissues where glucocorticoids inhibit its expression. | ||||||