ZNF486 Activators
ZNF486 can influence the protein's activity through various intracellular signaling pathways. Forskolin acts by directly stimulating adenylate cyclase, thereby raising the levels of cyclic AMP (cAMP) within the cell. The increase in cAMP activates protein kinase A (PKA), a kinase that can phosphorylate a myriad of proteins, including transcription factors which may interact with ZNF486, resulting in its activation. Similarly, IBMX operates by inhibiting phosphodiesterases, leading to an accumulation of cAMP and subsequent PKA activation, which then could lead to the activation of ZNF486. Dibutyryl cAMP, a cAMP analog, bypasses cellular receptors and directly activates PKA, offering another route to the phosphorylation and activation of proteins associated with ZNF486.
In addition to the cAMP pathway, other chemical activators work through different mechanisms. PMA, for instance, is a known activator of protein kinase C (PKC), which sets off a cascade of phosphorylation events that may culminate in the activation of ZNF486. Ionomycin and A23187 both act as ionophores that significantly elevate intracellular calcium levels, which can activate calmodulin-dependent kinases, potentially influencing the phosphorylation state and activity of ZNF486. Epigallocatechin gallate, by inhibiting DNA methyltransferases, may lead to a change in the expression of genes and subsequent activation of proteins that interact with ZNF486. Resveratrol's activation of SIRT1, a deacetylase, can modulate protein activity by deacetylation, which may affect proteins associated with ZNF486. Spermidine, through the induction of autophagy, could lead to the upregulation of proteins that activate ZNF486. Furthermore, retinoic acid, by interacting with its nuclear receptors, can upregulate genes whose protein products can interact with and activate ZNF486. Lastly, anacardic acid, through its inhibition of histone acetyltransferases, may lead to alterations in chromatin structure and gene expression, thereby affecting proteins that are involved in the activation of ZNF486.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular levels of cAMP, which can lead to the activation of protein kinase A (PKA). PKA can phosphorylate transcription factors and other proteins, potentially leading to the activation of ZNF486. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, which increases cAMP levels by preventing its breakdown. Elevated cAMP activates PKA, which then could phosphorylate and activate ZNF486 or proteins that interact with and activate ZNF486. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can lead to downstream signaling pathways that activate transcription factors or other proteins that could directly activate ZNF486 through phosphorylation or other post-translational modifications. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore for calcium, increasing intracellular calcium levels. Increased calcium can activate calmodulin-dependent kinase, which in turn could activate ZNF486 through phosphorylation or influence proteins that interact with ZNF486. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate can inhibit DNA methyltransferases, potentially leading to demethylation of DNA and activation of certain genes. This could lead to the activation of proteins that interact directly with ZNF486, leading to its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP is a cell-permeable cAMP analog that activates PKA. Activated PKA can phosphorylate proteins that may be involved in the activation of ZNF486, though the direct interaction with ZNF486 is not established. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is known to activate SIRT1, a deacetylase that can modulate the activity of transcription factors and other proteins. SIRT1 activation could lead to the deacetylation of proteins that interact with and activate ZNF486. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine can induce autophagy, during which cellular components are recycled. This process might upregulate proteins that interact directly with ZNF486, leading to its activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences gene expression through its nuclear receptors. This could lead to the upregulation of proteins that interact with ZNF486, potentially resulting in the activation of ZNF486. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that can alter gene expression patterns. This could lead to changes in the expression of proteins that interact with and activate ZNF486. | ||||||