ZNF440 Activators
ZNF440 activators predominantly target the RNA polymerase II pathway, aiming to enhance or modulate its associated transcriptional activities. These activators often influence the broader transcriptional machinery, creating a cellular environment where the regulatory role of ZNF440 becomes vital. For instance, compounds like DRB and α-Amanitin work by inhibiting RNA polymerase II-dependent transcription. Their actions underscore the importance of ZNF440 as they amplify its negative regulatory role, emphasizing its significance in the RNA polymerase II transcriptional network.
On the other hand, agents such as Caffeine and Sorafenib, while having broader cellular targets, indirectly affect the RNA polymerase II pathway. By influencing various transcription-associated pathways or the general cellular milieu, these compounds indirectly emphasize ZNF440's regulatory effects. Another class of activators, including Actinomycin D and Triptolide, interfere directly with transcriptional processes, either by interacting with DNA or targeting transcription factors. Their presence highlights ZNF440's regulatory function, indicating its importance in the broader transcriptional landscape. The emphasis, thus, remains on shaping the cellular transcriptional environment, highlighting ZNF440's predicted roles and functions.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB is a specific inhibitor of RNA polymerase II-dependent transcription. By inhibiting the general transcription machinery, it can modulate the negative regulation activity of ZNF440 by creating an environment where its role becomes more crucial. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
α-Amanitin binds directly to RNA polymerase II and inhibits its activity. This binding can indirectly emphasize the regulatory role of ZNF440 in transcription processes by RNA polymerase II. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Known to affect multiple cellular pathways, including ATM/ATR kinases involved in DNA damage response. By modulating this pathway, it can influence RNA polymerase II's activity, indirectly affecting ZNF440's regulatory role. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $31.00 | ||
Phenanthroline is a metal-chelating agent that can inhibit RNA polymerase II by depriving it of essential metal ions. Its action can amplify the negative regulatory effects of ZNF440. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA at the transcription initiation complex and can prevent RNA elongation by RNA polymerase II. Its presence can underscore the importance of ZNF440 in the transcriptional regulatory network. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits RNA polymerase II transcription by directly binding to XPB, a subunit of the TFIIH transcription factor. This action can potentially elevate the regulatory effects of ZNF440. | ||||||
4-Amino-1,8-naphthalimide | 1742-95-6 | sc-200125 sc-200125A | 20 mg 100 mg | $78.00 $310.00 | 4 | |
ARC is an inhibitor of RNA polymerase II transcription initiation. Its effects can set a stage for ZNF440 to further exert its negative regulatory influences on transcription. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
While primarily a kinase inhibitor, its broad activity can affect various transcription-related pathways, potentially magnifying the regulatory role of ZNF440 in certain contexts. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $81.00 $260.00 | 6 | |
An inhibitor of protein phosphatases 1 and 2A, its effects on dephosphorylation can indirectly modulate RNA polymerase II transcription, possibly accentuating ZNF440's function. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, affecting DNA replication and transcription processes. By modulating transcriptional dynamics, it can indirectly influence ZNF440's regulatory function. | ||||||