ZNF384 Activators
ZNF384, a zinc finger protein, plays a crucial role in transcriptional regulation and chromatin remodeling. It functions as a transcription factor involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. Activation of ZNF384 is tightly regulated by a myriad of signaling pathways and cellular factors. Chemical activators such as forskolin, sodium butyrate, and curcumin exert their effects by modulating intracellular signaling cascades, leading to the phosphorylation and activation of ZNF384. Similarly, retinoic acid and resveratrol activate ZNF384 by influencing histone acetylation status, thereby promoting chromatin accessibility and ZNF384-mediated transcription. These mechanisms highlight the diverse regulatory networks governing ZNF384 activity, emphasizing its importance in cellular homeostasis and gene expression regulation.
Furthermore, compounds like epigallocatechin gallate (EGCG), quercetin, and genistein activate ZNF384 through their interactions with specific cellular receptors or signaling molecules. EGCG, for instance, modulates multiple signaling pathways to enhance ZNF384 phosphorylation and DNA binding, leading to transcriptional activation of target genes. Additionally, berberine and nicotinamide riboside regulate ZNF384 activity by altering cellular metabolic processes, highlighting the interconnectedness between metabolic status and transcriptional regulation. Overall, the multifaceted mechanisms underlying ZNF384 activation underscore its significance as a central player in cellular physiology and gene expression regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates ZNF384 by stimulating adenylate cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP levels activate protein kinase A (PKA), which phosphorylates and activates ZNF384, enhancing its transcriptional activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate activates ZNF384 through histone deacetylase (HDAC) inhibition. By blocking HDAC activity, sodium butyrate promotes histone acetylation, facilitating chromatin accessibility and ZNF384 binding to target gene promoters, thus activating transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates ZNF384 by modulating various signaling pathways, including MAPK/ERK and PI3K/AKT. These pathways converge to phosphorylate ZNF384, promoting its nuclear translocation and transcriptional activation of target genes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid activates ZNF384 by binding to retinoic acid receptors (RARs), forming a complex that binds to retinoic acid response elements (RAREs) in target gene promoters. This leads to recruitment of co-activators and enhanced ZNF384-mediated transcription. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates ZNF384 by inhibiting SIRT1, a histone deacetylase. Suppression of SIRT1 activity increases histone acetylation, promoting chromatin remodeling and facilitating ZNF384 binding to target gene promoters, thereby activating transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates ZNF384 by modulating multiple signaling pathways, including PI3K/AKT and JAK/STAT. Activation of these pathways enhances ZNF384 phosphorylation, leading to increased DNA binding and transcriptional activation of target genes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein activates ZNF384 through estrogen receptor (ER) modulation. Binding of genistein to ER stimulates downstream signaling cascades that converge on ZNF384, promoting its phosphorylation and subsequent activation of target genes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates ZNF384 by modulating the NF-κB signaling pathway. Inhibition of NF-κB activity by quercetin prevents its translocation to the nucleus, thereby enhancing ZNF384-mediated transcription of target genes involved in cellular processes. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates ZNF384 by inhibiting AMP-activated protein kinase (AMPK). Suppression of AMPK activity leads to decreased phosphorylation of ZNF384, promoting its nuclear translocation and transcriptional activation of target genes implicated in various pathways. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside activates ZNF384 by enhancing NAD+ levels. Increased NAD+ availability stimulates sirtuin activity, resulting in ZNF384 deacetylation and activation. This facilitates ZNF384-mediated transcription of genes associated with cellular processes. | ||||||