ZNF333 Inhibitors
Chemical inhibitors of ZNF333 can significantly alter its functional activity by targeting various signaling pathways and kinases with which ZNF333 may interact. Staurosporine, a known kinase inhibitor, can impede the phosphorylation processes essential for ZNF333 activity by broadly inhibiting protein kinases. Similarly, Bisindolylmaleimide I can suppress the activity of protein kinase C (PKC), which may be critical for ZNF333's function if PKC-mediated signaling is involved. Furthermore, LY294002 can block the PI3K/Akt pathway, potentially preventing the activation of downstream proteins that are necessary for the regulation of ZNF333. PD98059, as a MEK inhibitor, can disrupt the MAPK/ERK pathway, thereby potentially reducing the activity of proteins that control ZNF333 function. SB203580 specifically inhibits p38 MAP kinase, which might decrease the activity of proteins in the p38 MAPK pathway that regulate ZNF333.
In addition to these inhibitors, SP600125 can decrease ZNF333 activity by inhibiting the JNK pathway, which may affect the regulatory proteins interacting with ZNF333. Rapamycin, an inhibitor of mTOR, can affect protein synthesis regulation, thereby influencing proteins that are involved in the modulation of ZNF333's activity. Y-27632 targets ROCK kinase, which, by controlling cytoskeletal organization, can influence the interaction between ZNF333 and its regulatory proteins. PD173074, which inhibits FGFR tyrosine kinase, can prevent activation of downstream signaling that includes proteins crucial for ZNF333's function. PP2, an inhibitor of Src family tyrosine kinases, can obstruct the functional interactions between ZNF333 and proteins regulated by Src kinases. Lastly, PD168393 and Chelerythrine, both targeting EGFR and PKC respectively, can disrupt further downstream signaling pathways, leading to the inhibition of ZNF333.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. Given that ZNF333 is a zinc finger protein, it might interact with kinases for proper function. Staurosporine inhibits these kinases directly, leading to a reduction in phosphorylation-dependent functional activity of ZNF333. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I targets protein kinase C (PKC). If ZNF333's activity is contingent upon PKC-mediated signaling, this inhibitor will block the pathway and subsequently inhibit the functional activity of ZNF333. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of the PI3K/Akt pathway. By blocking PI3K, LY294002 prevents the activation of Akt, which may be necessary for the phosphorylation of proteins that interact with ZNF333, thereby inhibiting its functional activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor which would block the MAPK/ERK pathway. As this pathway is important for the regulation of various proteins, inhibition by PD98059 could lead to a reduction in the activity of proteins that regulate the functional activity of ZNF333. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 MAPK can decrease the activity of proteins downstream in the signaling pathway, which may include regulatory proteins that are necessary for ZNF333's function, thereby inhibiting ZNF333. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits the JNK pathway, which could regulate proteins interacting with ZNF333. By inhibiting JNK, SP600125 would lead to decreased function of these regulatory proteins, therefore inhibiting the functional activity of ZNF333. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is involved in the regulation of protein synthesis. Proteins that regulate ZNF333 might be affected by this inhibition, leading to a decrease in the functional activity of ZNF333. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of ROCK kinase. By inhibiting ROCK, which may control cytoskeletal organization that affects proteins interacting with ZNF333, the functional activity of ZNF333 would be inhibited. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $46.00 $140.00 $680.00 | 16 | |
PD173074 is a specific inhibitor of the FGFR tyrosine kinase. This inhibition could block downstream signaling pathways that include regulatory proteins necessary for ZNF333's activity, thus inhibiting ZNF333. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an inhibitor of Src family tyrosine kinases. If proteins that are regulated by Src kinases interact with ZNF333 for its function, PP2 would inhibit these interactions, thereby inhibiting the functional activity of ZNF333. | ||||||