ZNF3 Inhibitors
ZNF3 inhibitors represent a class of chemical compounds designed to target the function of the zinc finger protein 3 (ZNF3), which belongs to a larger family of zinc finger (ZNF) proteins. ZNF proteins are characterized by their zinc finger domains, which typically bind to DNA, RNA, or proteins, and they are involved in a wide range of cellular processes, including transcriptional regulation, chromatin remodeling, and signal transduction. ZNF3 is particularly involved in regulating transcription by binding specific DNA sequences and interacting with other regulatory proteins. The inhibition of ZNF3 results in the disruption of these regulatory pathways, which can lead to significant shifts in gene expression patterns. This makes ZNF3 inhibitors useful in probing the function of ZNF3 and understanding its role in transcriptional regulation.
From a biochemical perspective, ZNF3 inhibitors typically interact with the zinc finger domains of the protein or affect its interaction with other molecules. These compounds can exhibit high specificity for ZNF3 by recognizing the unique conformational features of its zinc finger motifs. Researchers often focus on designing inhibitors that either chelate the zinc ion, which is essential for the structural integrity of the zinc finger domains, or disrupt the protein-protein interactions facilitated by ZNF3. The development and study of ZNF3 inhibitors are critical in elucidating the molecular mechanisms by which ZNF3 contributes to various cellular processes. By inhibiting ZNF3, researchers can uncover its role in epigenetic regulation and transcriptional networks, ultimately advancing our understanding of how zinc finger proteins control complex biological pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent may cause the demethylation of cytosine bases in the ZNF3 gene promoter, leading to a reduction in transcriptional activity and subsequent downregulation of ZNF3 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
By inhibiting DNA methyltransferases, 5-Aza-2′-Deoxycytidine could decrease DNA methylation levels at the ZNF3 gene locus, thereby reducing ZNF3 gene transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, this compound can lead to increased acetylation of histones near ZNF3, resulting in a less condensed chromatin state and a decrease in ZNF3 gene transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid may remove acetyl groups from histone proteins around the ZNF3 gene, resulting in a tighter chromatin structure that inhibits the initiation of ZNF3 transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
This short-chain fatty acid can inhibit histone deacetylase, leading to hyperacetylation of histones and a decrease in the expression of ZNF3 by altering the chromatin structure. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG 108 potentially blocks DNA methylation by targeting DNA methyltransferases, which might result in a lowered expression of ZNF3 through changes in chromatin structure. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
By binding to GC-rich DNA sequences, mithramycin A could competitively inhibit the binding of transcription factors to the ZNF3 promoter, leading to decreased ZNF3 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA, which may obstruct RNA polymerase movement and reduce transcription across the ZNF3 gene, leading to a reduction in ZNF3 mRNA levels. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
This diterpene triepoxide is known to inhibit the transcription of certain genes; it could theoretically repress the initiation phase of ZNF3 gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid may repress ZNF3 transcription by altering the recruitment and binding of transcription factors and other co-regulatory proteins to the ZNF3 gene promoter. | ||||||