ZNF294 Activators
ZNF294 activators comprise a class of chemicals designed to modulate the activity of the Zinc Finger Protein 294 (ZNF294), which is part of a larger family of zinc finger proteins known for their roles in DNA binding and the regulation of gene expression. Zinc finger proteins such as ZNF294 typically feature finger-like protrusions that bind zinc ions and enable the protein to interact with DNA molecules, thereby influencing transcriptional activity.
Direct ZNF294 activators are likely to function by binding to the protein in a manner that enhances its interaction with DNA. This could involve stabilizing the structure of ZNF294's zinc finger domains or inducing a configuration that increases its binding affinity to specific gene promoter regions. The result of such activation would be altered expression of genes under the regulatory influence of ZNF294, with the activators potentiating the protein's ability to modulate transcriptional activity either by recruiting transcriptional machinery or by facilitating the assembly of multiprotein complexes that govern transcription. On the other hand, indirect ZNF294 activators may not interact with the protein directly but could exert their effects by modulating the cellular environment in which ZNF294 operates. Such effects could include the upregulation of ZNF294 gene expression, thereby increasing the amount of protein available for DNA binding, or the alteration of post-translational modifications of ZNF294, which can impact its stability, cellular localization, or interaction with other transcriptional regulators. Furthermore, indirect activation could be achieved by influencing signaling pathways that regulate ZNF294 function, ultimately affecting the protein's role in gene expression.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a histone deacetylase (HDAC) inhibitor that can promote the acetylation of histones, thereby loosening the chromatin structure. This enhances the accessibility of transcription factors and co-activators to the promoter regions of genes, including ZNF294, increasing their transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that prevents DNA methylation, a process often linked to gene silencing. By inhibiting methylation, it can potentially increase the expression of ZNF294 if its promoter region is normally methylated. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is another HDAC inhibitor that promotes acetylation of histones, thereby enhancing gene transcription. It may increase the transcription of ZNF294 by loosening the chromatin structure. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A inhibits SP1, a transcription factor that binds to GC-rich promoter regions. If SP1 negatively regulates ZNF294, this drug can potentially enhance the expression of ZNF294. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, leading to DNA damage and the activation of p53 pathway. If ZNF294 transcription is under the control of p53, this drug can potentially enhance ZNF294 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, leading to the activation of PKA. If ZNF294 is a target of PKA, it can promote the activity of ZNF294. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a ligand for the retinoic acid receptor (RAR), which can modulate gene expression. If ZNF294 is a target of RAR, it can enhance the transcription of ZNF294. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid receptor agonist. If ZNF294 is a target of the glucocorticoid receptor, it can enhance the transcription of ZNF294. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation. If ZNF294 is a target of mTOR, its expression can be enhanced in response to mTOR inhibition. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride inhibits GSK3, a kinase involved in various signaling pathways. If ZNF294 is a target of GSK3, its expression can be enhanced in response to GSK3 inhibition. | ||||||