ZNF248 Inhibitors
ZNF248 inhibitors encompass a range of compounds that affect various cellular pathways and processes, ultimately leading to the downregulation of ZNF248 activity. Kinase inhibitors, such as those that target broad-spectrum kinases, impede phosphorylation events that are crucial for the activation and function of many transcription factors, including ZNF248. The inhibition of specific kinases involved in the PI3K/Akt and MAPK/ERK pathways by certain molecules results in reduced transcriptional activity of ZNF248, as these pathways play a significant role in modulating the availability and activity of transcription factors. In addition to kinase inhibitors, compounds that hinder RNA polymerase II activation directly affect the transcriptional capabilities of ZNF248 by disrupting the initiation of transcription at target gene promoters.
Other inhibitors operate by altering the protein stability and turnover that are essential for maintaining ZNF248 function. Proteasome inhibitors, for instance, prevent the degradation of regulatory proteins that can inhibit transcription factors such as ZNF248, leading to an indirect reduction in its activity. Similarly, compounds that block protein synthesis or destabilize client proteins can indirectly inhibit ZNF248 by affecting the proteins that regulate its stability and activity. Inhibitors that interfere with the epigenetic landscape, such as DNA methyltransferase and histone deacetylase inhibitors, can also lead to a decrease in ZNF248 expression by modifying the epigenetic state of its gene promoter or by changing the expression of genes that ZNF248 itself regulates.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
A potent kinase inhibitor that disrupts protein phosphorylation processes, indirectly inhibiting ZNF248 by preventing the phosphorylation events required for its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A phosphoinositide 3-kinase inhibitor which impedes the PI3K/Akt pathway, leading to reduced transcriptional activity of ZNF248 as this pathway modulates transcription factor availability. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An inhibitor of MEK, which in turn reduces activation of the MAPK/ERK pathway. Since this pathway is involved in the regulation of gene expression, ZNF248's function as a transcription factor is indirectly inhibited. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A diterpene triepoxide that inhibits transcription factors by preventing RNA polymerase II activation, thereby decreasing the transcriptional activity of ZNF248. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that can lead to reduced levels of transcription factors by preventing the degradation of regulatory proteins that inhibit transcription factors like ZNF248. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that causes hypomethylation of DNA, potentially reducing the expression of ZNF248 by altering the epigenetic state of its gene promoter. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that leads to a more open chromatin structure and may decrease the transcriptional activity of ZNF248 by altering the expression of genes it regulates. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
An inhibitor of eukaryotic protein synthesis which can indirectly inhibit ZNF248 by disrupting the synthesis of proteins that are necessary for its function. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
A cyclin-dependent kinase inhibitor that may impede cell cycle progression, indirectly affecting ZNF248's role in the transcription regulation of genes involved in cell cycle control. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that could lead to the accumulation of misfolded proteins, indirectly inhibiting ZNF248 by disrupting cellular homeostasis and transcription factor dynamics. | ||||||