ZNF221 Inhibitors
Chemical inhibitors of ZNF221, a zinc finger protein, are diverse in their mechanisms of action but converge on the common endpoint of modulating the protein's function by affecting its phosphorylation status. Staurosporine, a non-selective protein kinase inhibitor, acts broadly to prevent kinases from phosphorylating ZNF221, which is crucial for its DNA-binding ability. Similarly, PD98059 and U0126 target MEK1/2 specifically, leading to downstream reduction in ERK activity, a kinase that can phosphorylate ZNF221. By inhibiting MEK and subsequently ERK, these inhibitors reduce ZNF221's phosphorylation and subsequent DNA-binding activity. LY294002 and Wortmannin both target PI3K, reducing Akt-mediated phosphorylation of ZNF221. This PI3K/Akt pathway is a key regulator of phosphorylation and inhibition by these chemicals results in decreased functionality of ZNF221.
Further, SP600125 inhibits c-Jun N-terminal kinase (JNK) and SB203580 selectively inhibits p38 MAP kinase, both of which are important modulators of protein phosphorylation. Their inhibition can lead to reduced phosphorylation of ZNF221, altering its activity. GF109203X targets protein kinase C (PKC), another kinase involved in the phosphorylation of a multitude of proteins, including ZNF221. By inhibiting PKC, GF109203X decreases phosphorylation levels of ZNF221. PP2, an inhibitor of Src family kinases, by obstructing kinases in this family, can also lead to decreased phosphorylation and activity of ZNF221. Additionally, SB431542 inhibits TGF-β receptor ALK receptors, which can modulate signaling pathways affecting the phosphorylation state of ZNF221. Finally, Y-27632 and Rapamycin act on Rho-associated protein kinase (ROCK) and mammalian target of rapamycin (mTOR) respectively, each influencing the phosphorylation and function of ZNF221 through their respective pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent non-selective inhibitor of protein kinases. ZNF221, being a zinc finger protein, is modulated by phosphorylation which affects its DNA-binding affinity. Staurosporine inhibits protein kinases that could phosphorylate ZNF221, thereby inhibiting ZNF221's ability to bind DNA. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which is upstream of protein kinases that might phosphorylate ZNF221. By inhibiting MEK, PD98059 would decrease the activation of ERK, which in turn could inhibit the phosphorylation of ZNF221, resulting in reduced DNA-binding activity of ZNF221. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 selectively inhibits phosphoinositide 3-kinases (PI3K). PI3K/Akt signaling can impact the phosphorylation of proteins including those like ZNF221. By inhibiting PI3K, LY294002 can prevent Akt-mediated phosphorylation of ZNF221, inhibiting its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which can regulate the activity of a range of proteins through phosphorylation. By inhibiting JNK, SP600125 could reduce the phosphorylation and thus the activity of ZNF221. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. This kinase is involved in modulating phosphorylation states of various proteins. SB203580 can inhibit the phosphorylation of ZNF221 by p38 MAP kinase, resulting in inhibition of ZNF221's activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2. By inhibiting these kinases, U0126 prevents the activation of the downstream kinase ERK, which is potentially involved in phosphorylating ZNF221. Inhibition of MEK1/2 by U0126 would inhibit ZNF221 activity by reducing its phosphorylation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. Similar to LY294002, by inhibiting PI3K, wortmannin can reduce Akt-mediated phosphorylation of ZNF221, leading to functional inhibition of the protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin specifically inhibits mTOR, which is part of the PI3K/AKT/mTOR pathway, a signaling pathway that can influence the phosphorylation state of proteins such as ZNF221. Inhibition of mTOR by rapamycin can lead to the inhibition of ZNF221's activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is an inhibitor of Rho-associated protein kinase (ROCK). ROCK can indirectly influence the phosphorylation state of a variety of proteins. By inhibiting ROCK, Y-27632 could inhibit phosphorylation of ZNF221, thereby inhibiting its activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF109203X is a potent inhibitor of protein kinase C (PKC). PKC is known to phosphorylate a multitude of proteins. By inhibiting PKC, GF109203X can inhibit phosphorylation of ZNF221, leading to its functional inhibition. | ||||||