ZNF214 Inhibitors
Chemical inhibitors of ZNF214 can interfere with various signaling pathways and cellular processes that are essential for the protein's function. PD98059 acts by specifically inhibiting MEK, which is upstream in the signaling cascade that leads to the activation of transcription factors and other proteins; this inhibition can prevent the phosphorylation and subsequent activation of proteins that may stabilize or increase the functional activity of ZNF214. LY294002, another inhibitor, targets phosphoinositide 3-kinases (PI3K), thereby reducing the phosphorylation of proteins within the PI3K/AKT pathway, a critical pathway for many proteins, including ZNF214. This reduction can lead to a decrease in the functional activity of ZNF214. Similarly, SP600125 inhibits the JNK pathway, which can regulate the activity of transcription factors, including ZNF214, by altering their phosphorylation state, thereby inhibiting ZNF214 activity.
SB203580, U0126, and SL327 are specific inhibitors of p38 MAP kinase, MEK1/2, and both MEK1 and MEK2, respectively. These inhibitors disrupt signaling pathways that involve these kinases, which can impact the phosphorylation and thus the activation state of ZNF214, leading to its inhibition. Wortmannin and Rapamycin target other crucial kinases in the cell, PI3K and mTOR, respectively, both of which are involved in pathways that regulate protein synthesis and cell growth, important processes for the function of ZNF214. By preventing these pathways from functioning correctly, the activity of ZNF214 can be inhibited. Y-27632 and GF109203X inhibit ROCK and PKC, respectively, and these kinases can influence ZNF214 activity by altering actin cytoskeleton dynamics and phosphorylation patterns. PP2 acts on Src family kinases, which are involved in multiple signaling pathways that can modulate the phosphorylation and functional state of proteins like ZNF214. Lastly, SB431542 inhibits ALK receptors, which are part of the TGF-β signaling pathway. By blocking these pathways, the inhibitor can decrease the regulatory influence of ZNF214 on gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a specific inhibitor of mitogen-activated protein kinase kinase (MEK), which indirectly leads to inhibition of ZNF214 by preventing the activation of downstream targets that could be involved in the stabilization or functional activity of ZNF214. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K), which can inhibit ZNF214 by reducing the phosphorylation of downstream targets that may be involved in ZNF214-mediated signaling pathways crucial for its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in cell signaling pathways that can regulate the activity of transcription factors like ZNF214 by altering their phosphorylation state and, consequently, their activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAP kinase, which can inhibit ZNF214 function by disrupting signaling pathways that rely on p38 MAP kinase activity, potentially affecting the phosphorylation and activation state of ZNF214. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which can inhibit ZNF214 by impeding the MEK/ERK pathway, potentially affecting the phosphorylation and regulatory functions of ZNF214 in the cell. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, which can inhibit ZNF214 by preventing the activation of the AKT signaling pathway, thereby influencing the post-translational modifications and activity of ZNF214. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, which can inhibit ZNF214 by disrupting the mTOR signaling pathway, a key regulator of protein synthesis and cell growth that may be necessary for the proper functioning of ZNF214. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of the Rho-associated protein kinase (ROCK), which can inhibit ZNF214 by altering the actin cytoskeleton dynamics and cellular processes that could be essential for ZNF214's role in gene expression. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
GF109203X, also known as bisindolylmaleimide I, is a protein kinase C (PKC) inhibitor, which can inhibit ZNF214 by impeding the signaling pathways that involve PKC, potentially affecting ZNF214's activity through alterations in phosphorylation patterns. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an Src family kinase inhibitor, which can inhibit ZNF214 by disrupting Src family kinase-mediated signaling pathways, potentially impacting the phosphorylation and functional state of ZNF214. | ||||||