ZNF211 Inhibitors
Chemical inhibitors of ZNF211 include a variety of compounds that target specific signaling pathways and cellular processes to functionally inhibit the protein's activity. Palbociclib, a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6, disrupts the phosphorylation of proteins that are essential for the cell cycle-dependent regulation of ZNF211, resulting in its functional inhibition. Similarly, Alsterpaullone acts on cyclin-dependent kinase 1 (CDK1), altering the phosphorylation state of proteins that could be interacting with ZNF211, thus impairing its function. The inhibition of c-Jun N-terminal kinase (JNK) by SP600125 disrupts transcription factor activity, which likely plays a role in ZNF211's regulatory function.
Additionally, SB203580, by targeting p38 MAP kinase, interferes with the MAPK pathway, which may affect transcription factors and cofactors interacting with ZNF211, leading to an inhibition of its functional activity. PI3K inhibitors like LY294002 and Wortmannin may disrupt downstream signaling pathways, including AKT, which is involved in processes that could affect the regulation and function of ZNF211. MEK inhibitors PD98059 and U0126 reduce ERK pathway signaling, which is another route through which the functional activity of proteins regulating ZNF211 can be inhibited. Rapamycin's inhibition of the mTOR pathway could lead to a decrease in the activity of downstream proteins involved in ZNF211 regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
Palbociclib is a selective inhibitor of cyclin-dependent kinases CDK4 and CDK6. ZNF211 is regulated through cell cycle-dependent mechanisms, and inhibition of CDK4/6 by Palbociclib could lead to reduced phosphorylation of proteins necessary for ZNF211 function. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is known to inhibit cyclin-dependent kinase 1 (CDK1), which is involved in cell cycle regulation. CDK1 inhibition can alter the phosphorylation state of various proteins, potentially including those that interact with ZNF211, leading to its functional inhibition. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in stress and inflammatory responses. By inhibiting JNK, SP600125 can disrupt transcription factor activity that may be crucial for ZNF211 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 can impair the MAPK pathway, which can affect the activity of transcription factors and cofactors that interact with ZNF211, thereby inhibiting its function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). PI3K inhibition can disrupt downstream signaling pathways, including AKT, potentially affecting transcriptional regulators or cofactors necessary for ZNF211 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor, which works similarly to LY294002 by blocking the PI3K/AKT pathway, possibly leading to decreased function of proteins that are essential for the activity of ZNF211. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which is part of the MAPK/ERK pathway. Inhibition of MEK can lead to reduced activation of downstream proteins that may be required for ZNF211 function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is also a MEK inhibitor that can decrease ERK pathway signaling. By doing so, it could inhibit the functional activity of proteins that interact with or regulate ZNF211. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is important for protein synthesis and other cellular processes. Inhibition of mTOR can lead to decreased activity of downstream proteins that are involved in the regulation of ZNF211. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C (PKC). Inhibition of PKC can affect phosphorylation states of proteins in the signaling pathways that ZNF211 is involved in, leading to its functional inhibition. | ||||||