ZIP10 Activators
ZIP10 Activators belong to a distinct chemical class characterized by their ability to modulate the activity of the ZIP10 protein. These compounds play a crucial role in regulating the cellular transport of zinc ions, an essential trace element that serves as a cofactor for numerous enzymatic reactions and is vital for various physiological processes. ZIP10, also known as SLC39A10, is a member of the SLC39 family of zinc transporters, primarily responsible for facilitating the influx of zinc ions into cells. ZIP10 is found in various tissues throughout the body, including the brain, liver, and pancreas, and it plays a pivotal role in maintaining zinc homeostasis.
ZIP10 Activators are designed to enhance or inhibit the function of ZIP10, depending on their specific chemical properties. By targeting ZIP10, these compounds can modulate the cellular levels of zinc ions, which, in turn, can impact various biological processes. Understanding the mechanisms by which ZIP10 Activators interact with the ZIP10 protein is of great interest to researchers in the field of cellular and molecular biology. These compounds have the potential to shed light on the intricate regulatory pathways involving zinc transport and may have implications in a wide range of physiological and cellular processes. Further research into the precise mechanisms and effects of ZIP10 Activators may reveal novel insights into zinc homeostasis and cellular function, opening up new avenues for scientific exploration and potential applications in the future.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
As an ionophore, Zinc Pyrithione increases intracellular zinc levels by facilitating zinc transport across the cell membrane. Increased intracellular zinc availability can directly activate ZIP10 by creating a favorable gradient for zinc influx, enhancing the transport activity of ZIP10 as it functions to balance zinc homeostasis within cells. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $54.00 $84.00 $189.00 $204.00 $339.00 | 1 | |
Histidine serves as a zinc chelator and can increase free zinc concentration in serum. This elevation in zinc availability can indirectly enhance ZIP10 activity, as ZIP10 responds to zinc concentration gradients to transport zinc ions into cells, thus playing a critical role in zinc homeostasis. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide can influence cellular NAD+ metabolism, which is linked to various zinc-dependent enzymes. By modulating these enzyme activities, it may create conditions that necessitate increased zinc uptake via ZIP10, thereby indirectly enhancing ZIP10's transport function. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) can modulate intracellular signaling pathways that influence mineral ion channels and transporters. By affecting these pathways, PGE2 may upregulate the activity of ZIP10, which is essential for zinc uptake and contributes to the regulation of zinc homeostasis in response to physiological needs. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
As a glucocorticoid, Dexamethasone can influence the expression of metal ion transporters. It may indirectly enhance ZIP10 activity by affecting cellular pathways that modulate zinc homeostasis, which could lead to an increased functional demand for ZIP10-mediated zinc transport. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin can alter the metabolism of various trace elements, including zinc. By influencing cellular uptake and utilization of zinc, insulin might indirectly enhance ZIP10 activity, as it plays a crucial role in zinc homeostasis and could respond to changes in zinc requirements prompted by insulin signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid, a metabolite of vitamin A, influences gene expression, including genes related to metal ion homeostasis. It may indirectly enhance ZIP10 function by modulating the cellular zinc requirement and subsequently the activity of zinc transporters like ZIP10. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estrogen influences the expression of various proteins, including ion transporters. By modulating cellular growth and differentiation processes that require zinc, estrogen may indirectly enhance ZIP10 activity by increasing demand for cellular zinc uptake. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects various signaling pathways, including those involved in metal ion homeostasis. It could indirectly enhance ZIP10 function by modulating pathways that impact zinc transporter expression or activity, thereby increasing the cellular demand for zinc uptake that ZIP10 could provide. | ||||||