ZIP10 Antibody (1F6): sc-517167
- ZIP10 Antibody (1F6) is a mouse monoclonal IgG1 κ ZIP10 antibody provided at 100 µg/ml
- raised against amino acids 514-621 representing partial length ZIP10 of human origin
- recommended for detection of ZIP10 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ZIP10 Antibody (1F6). This work is in progress.
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ZIP10 Antibody (1F6) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZIP10 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). ZIP10 (1F6) antibody is available as the non-conjugated anti-ZIP10 monoclonal isotype antibody. ZIP10, also known as Zinc transporter ZIP10 and designated as Solute carrier family 39 member 10, is a multi-pass membrane protein characterized by seven transmembrane regions, which play a crucial role in zinc homeostasis within cells. ZIP10 is part of the ZIP transporter family, which increases intracellular zinc levels by facilitating zinc uptake from the extracellular environment. ZIP10 functions as a key cofactor in numerous enzymatic reactions and is involved in various cellular processes, including gene expression, immune function, and cell signaling. Dysregulation of ZIP10 expression has been linked to the invasiveness of several metastatic breast cancers, highlighting its potential as a biomarker for cancer progression and a target for therapeutic intervention. ZIP10 exhibits tissue-specific expression patterns and responds differently to varying zinc levels, making ZIP10 an important focus for research in both normal physiology and disease states.
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ZIP10 Antibody (1F6) References:
- Mammalian zinc transporters. | Liuzzi, JP. and Cousins, RJ. 2004. Annu Rev Nutr. 24: 151-72. PMID: 15189117
- Molecular cloning and functional characterization of novel zinc transporter rZip10 (Slc39a10) involved in zinc uptake across rat renal brush-border membrane. | Kaler, P. and Prasad, R. 2007. Am J Physiol Renal Physiol. 292: F217-29. PMID: 16804107
- Upregulation of Slc39a10 gene expression in response to thyroid hormones in intestine and kidney. | Pawan, K., et al. 2007. Biochim Biophys Acta. 1769: 117-23. PMID: 17292978
- ZnT5 variant B is a bidirectional zinc transporter and mediates zinc uptake in human intestinal Caco-2 cells. | Valentine, RA., et al. 2007. J Biol Chem. 282: 14389-93. PMID: 17355957
- Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells. | Kagara, N., et al. 2007. Cancer Sci. 98: 692-7. PMID: 17359283
- Regulation of ZIP and ZnT zinc transporters in zebrafish gill: zinc repression of ZIP10 transcription by an intronic MRE cluster. | Zheng, D., et al. 2008. Physiol Genomics. 34: 205-14. PMID: 18477665
- Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency. | Ryu, MS., et al. 2008. J Nutr. 138: 2076-83. PMID: 18936201
- Mammalian zinc transporters: nutritional and physiologic regulation. | Lichten, LA. and Cousins, RJ. 2009. Annu Rev Nutr. 29: 153-76. PMID: 19400752
- Zinc, alpha cells and glucagon secretion. | Egefjord, L., et al. 2010. Curr Diabetes Rev. 6: 52-7. PMID: 20034370
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZIP10 Antibody (1F6) | sc-517167 | 100 µg/ml | $322.00 |