Zfp872 Inhibitors
Zfp872 inhibitors represent a specialized class of chemical compounds designed to interfere with the function of Zfp872, a zinc finger protein. Zinc finger proteins are a broad family of transcription factors that typically bind to DNA, playing a crucial role in regulating gene expression. Zfp872, in particular, is a protein involved in the intricate processes of gene transcription and regulation, functioning through its characteristic zinc finger domains that recognize specific DNA sequences. The inhibition of Zfp872 disrupts its ability to regulate target genes, which can lead to downstream effects on cellular processes such as differentiation, proliferation, and metabolic control. Zfp872, as a transcriptional regulator, is part of a complex network, and inhibitors of this protein can potentially alter the expression of multiple genes within this network.
Chemically, Zfp872 inhibitors may be designed to target the DNA-binding domain of the protein or interfere with its zinc-coordinating site, which is essential for maintaining its structural integrity and functional capacity. Inhibitors could also block interactions between Zfp872 and other co-factors necessary for its role in gene regulation. Structurally, these inhibitors may incorporate elements that either chelate the zinc ions in the zinc finger domain or modify the local environment of the protein to prevent it from binding to its target DNA sequences. The study and design of Zfp872 inhibitors are of significant interest in the field of chemical biology, as they offer insights into the broader mechanisms of zinc finger protein functions and how small molecules can modulate transcriptional regulators at the molecular level. This, in turn, has important implications for understanding gene regulation pathways and cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC), which is involved in regulating the function of various zinc finger proteins including zinc finger protein 872 by altering their phosphorylation status. Inhibition of PKC can lead to decreased phosphorylation and thus functional inhibition of zinc finger protein 872. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide inhibits the transcription factor NF-kB, which regulates the expression of multiple zinc finger proteins. By inhibiting NF-kB, triptolide can diminish the functional interaction between NF-kB and zinc finger protein 872, leading to its inhibition. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can prevent the degradation of regulatory proteins that control zinc finger proteins, resulting in the accumulation of repressive regulatory proteins that inhibit the function of zinc finger protein 872. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK, which is part of the MAPK/ERK pathway. The MAPK/ERK pathway can regulate the activity of various transcription factors and thus could inhibit the transcriptional activity of zinc finger protein 872. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, and PI3K is involved in the AKT signaling pathway which can regulate transcription factors that interact with zinc finger proteins. Inhibition of this pathway can lead to reduced activity of zinc finger protein 872. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK, a kinase that modulates the activity of various transcription factors. Inhibition of p38 MAPK can result in decreased functional activity of transcription factors that regulate zinc finger protein 872. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine inhibits DNA methyltransferases, leading to reduced methylation, which can affect the binding of transcriptional repressors to DNA. This can lead to inhibition of transcription factors that regulate zinc finger protein 872. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is a cyclin-dependent kinase inhibitor. By inhibiting CDKs, it can affect the cell cycle and transcription factor activity, which can inhibit the regulatory functions of zinc finger protein 872. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which prevents activation of the ERK pathway. Since the ERK pathway can regulate transcription factor function, U0126 can inhibit the functional activity of zinc finger protein 872. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is implicated in the regulation of various transcription factors. By inhibiting JNK, SP600125 can reduce the functional activity of transcription factors that interact with zinc finger protein 872. | ||||||